{"doi":"10.1128/asmcr.00101-25","title":"Distinct memory CD4 <sup>+</sup> T cell subset tropism of two CCR5-tropic HIV-1 in a rapid progressor","abstract":"ABSTRACT Background Low HIV-1 infection level in the central memory CD4 + T cell subset is a hallmark of both non-progressive HIV infection and non-pathogenetic SIV infection in the natural hosts. However, an important gap in knowledge is whether CCR5-tropic HIV-1 variants have different memory CD4 + T cell subset preferences. Case Summary Here, we identified clear compartmentalization of two CCR5-tropic HIV-1 in different memory CD4 + T cell subsets in a rapid progressor. Participant 40512 was identified in the RV217 cohort. While the transmitted/founder (T/F) virus in 40512 was compartmentalized in the central memory CD4 + T cells, the superinfecting virus was compartmentalized in the effector memory CD4 + T cells. Both viruses rely on CCR5 to infect primary CD4 + T cells. The T/F virus is more than 100-fold more resistant to the CCR5 inhibitor Maraviroc than the superinfecting virus. Conclusion This case report demonstrates that CCR5 HIV-1 variants have distinct memory CD4 + T cell subset preferences in vivo . Because CD4 + T cell subset targeting is highly relevant for HIV-1 pathogenesis, understanding the underlying molecular mechanisms may provide deeper insights into HIV-1 therapeutics and functional cure.","journal":"ASM Case Reports","year":2025,"id":573406,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1480611,"name":"Yasmine Farah","orcid":null,"position":1,"is_corresponding":false},{"id":593568,"name":"Meera Bose","orcid":"0000-0003-4151-0958","position":2,"is_corresponding":false},{"id":369889,"name":"Eric Sanders‐Buell","orcid":"0000-0002-1694-0529","position":3,"is_corresponding":false},{"id":475413,"name":"David B. King","orcid":"0000-0001-6906-0982","position":4,"is_corresponding":false},{"id":905703,"name":"Leilani Francisco","orcid":"0000-0002-1074-6418","position":5,"is_corresponding":false},{"id":347960,"name":"Leigh Anne Eller","orcid":"0000-0003-2043-1513","position":6,"is_corresponding":false},{"id":979758,"name":"Abdur Rashid","orcid":"0000-0002-4539-5320","position":7,"is_corresponding":false},{"id":332552,"name":"Sodsai Tovanabutra","orcid":"0000-0002-5946-4227","position":8,"is_corresponding":false},{"id":1480612,"name":"N L Michael","orcid":null,"position":9,"is_corresponding":false},{"id":288619,"name":"Merlin L. Robb","orcid":"0000-0003-3949-9649","position":10,"is_corresponding":false},{"id":592584,"name":"Hongshuo Song","orcid":null,"position":11,"is_corresponding":false},{"id":228623,"name":"Manukumar Honnayakanahalli Marichannegowda","orcid":"0000-0002-6488-7136","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-19T02:57:32.445190Z","pmid":"41244297","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}