{"doi":"10.1128/aem.02233-06","title":"Inhibition of Quorum Sensing in\n            <i>Pseudomonas aeruginosa</i>\n            by\n            <i>N</i>\n            -Acyl Cyclopentylamides","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            <jats:italic>N</jats:italic>\n            -Octanoyl cyclopentylamide (C8-CPA) was found to moderately inhibit quorum sensing in\n            <jats:italic>Pseudomonas aeruginosa</jats:italic>\n            PAO1. To obtain more powerful inhibitors, a series of structural analogs of C8-CPA were synthesized and examined for their ability to inhibit quorum sensing in\n            <jats:italic>P. aeruginosa</jats:italic>\n            PAO1. The\n            <jats:italic>lasB</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            and\n            <jats:italic>rhlA</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            reporter assays revealed that the chain length and the ring structure were critical for C8-CPA analogs to inhibit quorum sensing.\n            <jats:italic>N</jats:italic>\n            -Decanoyl cyclopentylamide (C10-CPA) was found to be the strongest inhibitor, and its concentrations required for half-maximal inhibition for\n            <jats:italic>lasB</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            and\n            <jats:italic>rhlA</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            expression were 80 and 90 μM, respectively. C10-CPA also inhibited production of virulence factors, including elastase, pyocyanin, and rhamnolipid, and biofilm formation without affecting growth of\n            <jats:italic>P. aeruginosa</jats:italic>\n            PAO1. C10-CPA inhibited induction of both\n            <jats:italic>lasI</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            by\n            <jats:italic>N</jats:italic>\n            -(3-oxododecanoyl)-\n            <jats:sc>l</jats:sc>\n            -homoserine lactone (PAI1) and\n            <jats:italic>rhlA</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            by\n            <jats:italic>N</jats:italic>\n            -butanoyl-\n            <jats:sc>l</jats:sc>\n            -homoserine lactone (PAI2) in the\n            <jats:italic>lasI rhlI</jats:italic>\n            mutant of\n            <jats:italic>P. aeruginosa</jats:italic>\n            PAO1, indicating that C10-CPA interferes with the\n            <jats:italic>las</jats:italic>\n            and\n            <jats:italic>rhl</jats:italic>\n            quorum-sensing systems via inhibiting interaction between their response regulators (LasR and RhlR) and autoinducers.\n          </jats:p>","journal":"Applied and Environmental Microbiology","year":2007,"id":622553,"datarank":0.787053610824073,"base_score":5.247024072160486,"endowment":5.247024072160486,"self_citation_contribution":0.787053610824073,"citation_network_contribution":0.0,"self_endowment_contribution":0.787053610824073,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":189,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1608607,"name":"Tsukasa Ikeda","orcid":null,"position":1,"is_corresponding":false},{"id":1608608,"name":"Noboru Takiguchi","orcid":null,"position":2,"is_corresponding":false},{"id":1608610,"name":"Akio Kuroda","orcid":null,"position":3,"is_corresponding":false},{"id":1608614,"name":"Hisao Ohtake","orcid":null,"position":4,"is_corresponding":false},{"id":1608616,"name":"Junichi Kato","orcid":null,"position":5,"is_corresponding":false},{"id":1608606,"name":"Takenori Ishida","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Inhibition of Quorum Sensing in\n            <i>Pseudomonas aeruginosa</i>\n            by\n            <i>N</i>\n            -Acyl Cyclopentylamides","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            <jats:italic>N</jats:italic>\n            -Octanoyl cyclopentylamide (C8-CPA) was found to moderately inhibit quorum sensing in\n            <jats:italic>Pseudomonas aeruginosa</jats:italic>\n            PAO1. To obtain more powerful inhibitors, a series of structural analogs of C8-CPA were synthesized and examined for their ability to inhibit quorum sensing in\n            <jats:italic>P. aeruginosa</jats:italic>\n            PAO1. The\n            <jats:italic>lasB</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            and\n            <jats:italic>rhlA</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            reporter assays revealed that the chain length and the ring structure were critical for C8-CPA analogs to inhibit quorum sensing.\n            <jats:italic>N</jats:italic>\n            -Decanoyl cyclopentylamide (C10-CPA) was found to be the strongest inhibitor, and its concentrations required for half-maximal inhibition for\n            <jats:italic>lasB</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            and\n            <jats:italic>rhlA</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            expression were 80 and 90 μM, respectively. C10-CPA also inhibited production of virulence factors, including elastase, pyocyanin, and rhamnolipid, and biofilm formation without affecting growth of\n            <jats:italic>P. aeruginosa</jats:italic>\n            PAO1. C10-CPA inhibited induction of both\n            <jats:italic>lasI</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            by\n            <jats:italic>N</jats:italic>\n            -(3-oxododecanoyl)-\n            <jats:sc>l</jats:sc>\n            -homoserine lactone (PAI1) and\n            <jats:italic>rhlA</jats:italic>\n            -\n            <jats:italic>lacZ</jats:italic>\n            by\n            <jats:italic>N</jats:italic>\n            -butanoyl-\n            <jats:sc>l</jats:sc>\n            -homoserine lactone (PAI2) in the\n            <jats:italic>lasI rhlI</jats:italic>\n            mutant of\n            <jats:italic>P. aeruginosa</jats:italic>\n            PAO1, indicating that C10-CPA interferes with the\n            <jats:italic>las</jats:italic>\n            and\n            <jats:italic>rhl</jats:italic>\n            quorum-sensing systems via inhibiting interaction between their response regulators (LasR and RhlR) and autoinducers.\n          </jats:p>","is_dataset_classified":null,"base_score":5.247024072160486,"endowment":5.247024072160486,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17369333","pmcid":"PMC1907104","openalex_id":"https://openalex.org/W2138139413","authors":[],"funders":[],"total_grants":0,"fwci":3.2711,"citation_percentile":0.92890565,"influential_citations":0,"citation_trend":[{"year":2012,"count":9},{"year":2013,"count":16},{"year":2014,"count":18},{"year":2015,"count":11},{"year":2016,"count":10},{"year":2017,"count":7},{"year":2018,"count":11},{"year":2019,"count":15},{"year":2020,"count":11},{"year":2021,"count":9},{"year":2022,"count":9},{"year":2023,"count":12},{"year":2024,"count":7},{"year":2025,"count":9},{"year":2026,"count":3}],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1907104","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1907104","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AEM.02233-06","host_type":"publisher"},{"url":"https://doi.org/10.1128/aem.02233-06","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17369333","host_type":"repository"}],"fields_of_study":["Bacterial biofilms and quorum sensing","Antibiotic Resistance in Bacteria","Bacterial Genetics and Biotechnology"],"mesh_terms":["Adaptation, Physiological","Anti-Bacterial Agents","beta-Galactosidase","Cyclopentanes","Glycolipids","Homoserine","Pancreatic Elastase","Pseudomonas aeruginosa","Pyocyanine","4-Butyrolactone","Genes, Reporter","Biofilms","Virulence Factors","Quorum Sensing"],"keywords":["Quorum sensing","Pseudomonas aeruginosa","Autoinducer","Homoserine","Biofilm","Chemistry","Microbiology","Rhamnolipid","lac operon","Mutant","Pyocyanin","Virulence","Escherichia coli","Bacteria","Biochemistry","Biology","Gene","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T20:05:10.498996Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}