{"doi":"10.1128/aem.01840-18","title":"Regulatory Networks Governing Methionine Catabolism into Volatile Organic Sulfur-Containing Compounds in Clonostachys\n            <i>rosea</i>","abstract":"<jats:p>\n            Methionine shuttles organic nitrogen and plays a central role in nitrogen metabolism. Exogenous Met strongly induces the expression of\n            <jats:italic>ARO8-2</jats:italic>\n            and\n            <jats:italic>PDC</jats:italic>\n            , represses the expression of\n            <jats:italic>STR3</jats:italic>\n            , and generates volatile organic sulfur-containing compounds via the Ehrlich and demethiolation pathways. In this study, we used genetic, bioinformatic, and metabolite-based analyses to confirm that transcriptional control of the aminotransferase gene\n            <jats:italic>ARO8-2</jats:italic>\n            , the decarboxylase gene\n            <jats:italic>PDC</jats:italic>\n            , and the demethiolase gene\n            <jats:italic>STR3</jats:italic>\n            modulates Met catabolism into volatile organic sulfur-containing compounds. Importantly, we found that, in addition to the Ehrlich pathway, the demethiolation pathway was regulated by a nitrogen catabolite repression-sensitive regulatory pathway that controlled the transcription of genes required to catabolize poor nitrogen sources. This work significantly advances our understanding of nitrogen catabolite repression-sensitive transcriptional regulation of sulfur-containing amino acid catabolism and provides a basis for engineering Met catabolism pathways for the production of fuel and valuable flavor alcohols.\n          </jats:p>","journal":"Applied and Environmental Microbiology","year":2018,"id":16041,"datarank":0.50977433940749,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.16438657545838306,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.16438657545838306,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":7,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":119911,"name":"Kai-Zhi Jia","orcid":null,"position":1,"is_corresponding":false},{"id":119912,"name":"Ya-Jie Tang","orcid":null,"position":2,"is_corresponding":false},{"id":119910,"name":"Yang-Hua Xu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30217835","pmcid":"PMC6210120","openalex_id":"https://openalex.org/W2890649189","authors":[],"funders":[{"funder_name":"NSFC","grant_id":"31570054","title":null},{"funder_name":"NSFC","grant_id":"21625602","title":null}],"total_grants":2,"fwci":0.371,"citation_percentile":0.60926752,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":3},{"year":2022,"count":1},{"year":2024,"count":1},{"year":2025,"count":3}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://aem.asm.org/content/aem/84/22/e01840-18.full.pdf","host_type":"journal"},{"url":"https://aem.asm.org/content/aem/84/22/e01840-18.full.pdf","host_type":"BRONZE"},{"url":"https://aem.asm.org/content/aem/84/22/e01840-18.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AEM.01840-18","host_type":"publisher"},{"url":"https://doi.org/10.1128/aem.01840-18","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30217835","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6210120","host_type":"repository"}],"fields_of_study":["Polyamine Metabolism and Applications","Plant Gene Expression Analysis","Microbial Metabolic Engineering and Bioproduction","Chemistry","Medicine","Environmental Science","Biology","Carboxy-Lyases","Catabolite Repression","Fungal Proteins","Gene Expression Regulation, Fungal","Hypocreales","Metabolic Networks and Pathways","Methionine","Nitrogen","Saccharomyces cerevisiae","Sulfur Compounds","Volatile Organic Compounds"],"mesh_terms":["Carboxy-Lyases","Fungal Proteins","Hypocreales","Methionine","Nitrogen","Saccharomyces cerevisiae","Sulfur Compounds","Gene Expression Regulation, Fungal","Metabolic Networks and Pathways","Volatile Organic Compounds","Catabolite Repression"],"keywords":["Catabolite repression","Catabolism","Biochemistry","Methionine","Metabolic pathway","Sulfur","Chemistry","Gene","Repressor","Enzyme","Biology","Gene expression","Amino acid","Mutant","Organic chemistry","Regulatory Networks","Methionine Catabolism","Volatile Organic Sulfur-containing Compounds"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T20:03:59.543244Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}