{"doi":"10.1128/aem.01831-08","title":"Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant\n            <jats:italic>Staphylococcus aureus</jats:italic>\n            . This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.\n          </jats:p>","journal":"Applied and Environmental Microbiology","year":2009,"id":599359,"datarank":6.453413649061181,"base_score":5.0238805208462765,"endowment":5.0238805208462765,"self_citation_contribution":0.7535820781269416,"citation_network_contribution":5.699831570934239,"self_endowment_contribution":0.7535820781269416,"citer_contribution":5.699831570934239,"corpus_percentile":null,"corpus_rank":null,"citation_count":151,"citer_count":132,"citers_with_citation_signal":122,"citers_with_endowment":122,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1536067,"name":"Gary O’Flynn","orcid":null,"position":1,"is_corresponding":false},{"id":1536068,"name":"Jennifer Garry","orcid":null,"position":2,"is_corresponding":false},{"id":1536069,"name":"Jakki Cooney","orcid":null,"position":3,"is_corresponding":false},{"id":1536070,"name":"Aidan Coffey","orcid":null,"position":4,"is_corresponding":false},{"id":1536071,"name":"Gerald F. Fitzgerald","orcid":null,"position":5,"is_corresponding":false},{"id":679912,"name":"R. Paul Ross","orcid":"0000-0003-4876-8839","position":6,"is_corresponding":false},{"id":1536072,"name":"Olivia McAuliffe","orcid":null,"position":7,"is_corresponding":false},{"id":1536066,"name":"Marianne Horgan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant\n            <jats:italic>Staphylococcus aureus</jats:italic>\n            . This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.\n          </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://journals.asm.org/doi/pdf/10.1128/AEM.01831-08","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":[],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T01:01:02.732901Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}