{"doi":"10.1128/aem.01487-21","title":"Utilization Efficiency of Human Milk Oligosaccharides by Human-Associated\n                    <i>Akkermansia</i>\n                    Is Strain Dependent","abstract":"<jats:p>\n                    Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk and provide several benefits to developing infants, including the recruitment of beneficial bacteria to the human gut.\n                    <jats:italic>Akkermansia</jats:italic>\n                    strains are largely considered beneficial bacteria and have been detected in colostrum, breast milk, and young infants.\n                    <jats:named-content content-type=\"genus-species\">A. muciniphila</jats:named-content>\n                    Muc\n                    <jats:sup>T</jats:sup>\n                    belonging to the AmI phylogroup contributes to the HMO deconstruction capacity of the infant. Here, using phylogenomics, we examined the genomic capacities of four\n                    <jats:italic>Akkermansia</jats:italic>\n                    phylogroups to deconstruct HMOs.\n                  </jats:p>","journal":"Applied and Environmental Microbiology","year":2022,"id":594401,"datarank":0.6515708132780527,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":0.0,"self_endowment_contribution":0.6515708132780527,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1521574,"name":"Shanthi G. Parkar","orcid":"0000-0002-5737-7867","position":1,"is_corresponding":false},{"id":1521575,"name":"Nina Kirmiz","orcid":null,"position":2,"is_corresponding":false},{"id":1521576,"name":"Stephanie Hartel","orcid":null,"position":3,"is_corresponding":false},{"id":1116947,"name":"Erik Hearn","orcid":null,"position":4,"is_corresponding":false},{"id":1521577,"name":"Marziiah Hossine","orcid":null,"position":5,"is_corresponding":false},{"id":882953,"name":"Arinnae Kurdian","orcid":null,"position":6,"is_corresponding":false},{"id":1521578,"name":"Claudia Mendoza","orcid":null,"position":7,"is_corresponding":false},{"id":1267965,"name":"Katherine Orr","orcid":null,"position":8,"is_corresponding":false},{"id":1178226,"name":"Loren Padilla","orcid":null,"position":9,"is_corresponding":false},{"id":1521579,"name":"Katherine Ramirez","orcid":null,"position":10,"is_corresponding":false},{"id":1521580,"name":"Priscilla Salcedo","orcid":null,"position":11,"is_corresponding":false},{"id":971314,"name":"Erik Serrano","orcid":"0000-0003-4188-9080","position":12,"is_corresponding":false},{"id":279898,"name":"Biswa Choudhury","orcid":null,"position":13,"is_corresponding":false},{"id":1059148,"name":"Mousumi Paulchakrabarti","orcid":null,"position":14,"is_corresponding":false},{"id":382864,"name":"Craig T. Parker","orcid":"0000-0002-7719-8882","position":15,"is_corresponding":false},{"id":382859,"name":"Steven Huynh","orcid":"0000-0002-5940-606X","position":16,"is_corresponding":false},{"id":1150950,"name":"Kerry Cooper","orcid":null,"position":17,"is_corresponding":false},{"id":80286,"name":"Gilberto E. Flores","orcid":"0000-0002-3338-611X","position":18,"is_corresponding":false},{"id":1178227,"name":"Estefani Luna","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Utilization Efficiency of Human Milk Oligosaccharides by Human-Associated\n                    <i>Akkermansia</i>\n                    Is Strain Dependent","abstract":"<jats:p>\n                    Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk and provide several benefits to developing infants, including the recruitment of beneficial bacteria to the human gut.\n                    <jats:italic>Akkermansia</jats:italic>\n                    strains are largely considered beneficial bacteria and have been detected in colostrum, breast milk, and young infants.\n                    <jats:named-content content-type=\"genus-species\">A. muciniphila</jats:named-content>\n                    Muc\n                    <jats:sup>T</jats:sup>\n                    belonging to the AmI phylogroup contributes to the HMO deconstruction capacity of the infant. Here, using phylogenomics, we examined the genomic capacities of four\n                    <jats:italic>Akkermansia</jats:italic>\n                    phylogroups to deconstruct HMOs.\n                  </jats:p>","is_dataset_classified":null,"base_score":4.343805421853684,"endowment":4.343805421853684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34669436","pmcid":"PMC8752153","openalex_id":"https://openalex.org/W4288059046","authors":[],"funders":[{"funder_name":"HHS | NIH | National Institute of General Medical Sciences","grant_id":"SC2GM122620 and SC1GM136546","title":null},{"funder_name":"HHS | NIH | National Institute of General Medical Sciences","grant_id":"TL4GM118977 RL5GM118975 and UL1GM118976","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"RL5 GM118975","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"UL1 GM118976","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"SC2 GM122620","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"TL4 GM118977","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"SC1 GM136546","title":null},{"funder_name":"NLM NIH HHS","grant_id":"T15 LM009451","title":null},{"funder_name":"National Institutes of Health","grant_id":"5TL4GM118977-05","title":"BUILD@CSUN"},{"funder_name":"National Institutes of Health","grant_id":"5SC2GM122620-02","title":"Integrated studies into the genomic, metabolic, and cultivable diversity of the human gut symbiont Akkermansia muciniphila"},{"funder_name":"National Institutes of Health","grant_id":"5SC1GM136546-02","title":"Mechanisms and consequences of human milk oligosaccharide growth and bile stress across diverse strains of the potential therapeutic bacterium, Akkermansia muciniphila."},{"funder_name":"National Institutes of Health","grant_id":"5UL1GM118976-09","title":"BUILD PODER II"},{"funder_name":"National Institutes of Health","grant_id":"2RL5GM118975-06","title":"BUILD PODER II"}],"total_grants":13,"fwci":5.2225,"citation_percentile":0.96638353,"influential_citations":0,"citation_trend":[{"year":2022,"count":5},{"year":2023,"count":18},{"year":2024,"count":23},{"year":2025,"count":19},{"year":2026,"count":11}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1128/aem.01487-21","host_type":"journal"},{"url":"https://doi.org/10.1128/aem.01487-21","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AEM.01487-21","host_type":"publisher"},{"url":"https://europepmc.org/articles/PMC8752153","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8752153?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1101/2021.07.26.453919","host_type":""},{"url":"https://www.biorxiv.org/content/biorxiv/early/2021/07/28/2021.07.26.453919.full.pdf","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/34669436","host_type":""},{"url":"http://dx.doi.org/10.1128/AEM.01487-21","host_type":""},{"url":"https://dx.doi.org/10.1101/2021.07.26.453919","host_type":""},{"url":"https://dx.doi.org/10.1128/aem.01487-21","host_type":""}],"fields_of_study":["Infant Nutrition and Health","Digestive system and related health","Breastfeeding Practices and Influences","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Milk, Human","Humans","Oligosaccharides","Infant","Female","Verrucomicrobia","Gastrointestinal Microbiome","Akkermansia"],"keywords":["Strain (injury)","Akkermansia","Microbiology","Biology","Chemistry","Food science","Fermentation","Human Milk Oligosaccharides","Akkermansia Muciniphila","Glycoside Hydrolase (Gh)","Akkermansia Phylogroups","Gh95","Hmo Utilization","Fucosylated Hmo","Sialylated Hmo","Gh29","Milk, Human","Infant","Oligosaccharides","Microbial Ecology","Gastrointestinal Microbiome","Verrucomicrobia","Humans","Female"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. Zero hunger"},{"sdg_number":3,"sdg_label":"3. Good health"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"bioproject"},{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T14:29:54.794332Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}