{"doi":"10.1128/aac.45.5.1323-1336.2001","title":"Structural Comparison of Three Types of Staphylococcal Cassette Chromosome\n            <i>mec</i>\n            Integrated in the Chromosome in  Methicillin-Resistant\n            <i>Staphylococcus aureus</i>","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The β-lactam resistance gene\n            <jats:italic>mecA</jats:italic>\n            of\n            <jats:italic>Staphylococcus aureus</jats:italic>\n            is carried by a novel mobile genetic element, designated staphylococcal cassette chromosome\n            <jats:italic>mec</jats:italic>\n            (SCC\n            <jats:italic>mec</jats:italic>\n            ), identified in the chromosome of a Japanese methicillin-resistant\n            <jats:italic>S. aureus</jats:italic>\n            (MRSA) strain. We now report identification of two additional types of\n            <jats:italic>mecA</jats:italic>\n            -carrying genetic elements found in the MRSA strains isolated in other countries of the world. There were substantial differences in the size and nucleotide sequences between the elements and the SCC\n            <jats:italic>mec</jats:italic>\n            . However, new elements shared the chromosomal integration site with the SCC\n            <jats:italic>mec</jats:italic>\n            . Structural analysis of the new elements revealed that they possessed all of the salient features of the SCC\n            <jats:italic>mec</jats:italic>\n            : conserved terminal inverted repeats and direct repeats at the integration junction points, conserved genetic organization around the\n            <jats:italic>mecA</jats:italic>\n            gene, and the presence of cassette chromosome recombinase (\n            <jats:italic>ccr</jats:italic>\n            ) genes responsible for the movements of SCC\n            <jats:italic>mec</jats:italic>\n            . The elements, therefore, were considered to comprise the SCC\n            <jats:italic>mec</jats:italic>\n            family of staphylococcal mobile genetic elements together with the previously identified SCC\n            <jats:italic>mec</jats:italic>\n            . Among 38 epidemic MRSA strains isolated in 20 countries, 34 were shown to possess one of the three typical SCC\n            <jats:italic>mec</jats:italic>\n            elements on the chromosome. Our findings indicated that there are at least three distinct MRSA clones in the world with different types of SCC\n            <jats:italic>mec</jats:italic>\n            in their chromosome.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2001,"id":675779,"datarank":20.494401878371413,"base_score":6.8658910748834385,"endowment":6.8658910748834385,"self_citation_contribution":1.029883661232516,"citation_network_contribution":19.464518217138895,"self_endowment_contribution":1.029883661232516,"citer_contribution":19.464518217138895,"corpus_percentile":null,"corpus_rank":null,"citation_count":958,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":274950,"name":"Yuki Katayama","orcid":"0000-0002-7940-2322","position":1,"is_corresponding":false},{"id":1765703,"name":"Kazumi Asada","orcid":null,"position":2,"is_corresponding":false},{"id":1765704,"name":"Namiko Mori","orcid":null,"position":3,"is_corresponding":false},{"id":1765705,"name":"Kanae Tsutsumimoto","orcid":null,"position":4,"is_corresponding":false},{"id":1765706,"name":"Chuntima Tiensasitorn","orcid":null,"position":5,"is_corresponding":false},{"id":1634869,"name":"Keiichi Hiramatsu","orcid":null,"position":6,"is_corresponding":false},{"id":1765701,"name":"Teruyo Ito","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Structural Comparison of Three Types of Staphylococcal Cassette Chromosome\n            <i>mec</i>\n            Integrated in the Chromosome in  Methicillin-Resistant\n            <i>Staphylococcus aureus</i>","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The β-lactam resistance gene\n            <jats:italic>mecA</jats:italic>\n            of\n            <jats:italic>Staphylococcus aureus</jats:italic>\n            is carried by a novel mobile genetic element, designated staphylococcal cassette chromosome\n            <jats:italic>mec</jats:italic>\n            (SCC\n            <jats:italic>mec</jats:italic>\n            ), identified in the chromosome of a Japanese methicillin-resistant\n            <jats:italic>S. aureus</jats:italic>\n            (MRSA) strain. We now report identification of two additional types of\n            <jats:italic>mecA</jats:italic>\n            -carrying genetic elements found in the MRSA strains isolated in other countries of the world. There were substantial differences in the size and nucleotide sequences between the elements and the SCC\n            <jats:italic>mec</jats:italic>\n            . However, new elements shared the chromosomal integration site with the SCC\n            <jats:italic>mec</jats:italic>\n            . Structural analysis of the new elements revealed that they possessed all of the salient features of the SCC\n            <jats:italic>mec</jats:italic>\n            : conserved terminal inverted repeats and direct repeats at the integration junction points, conserved genetic organization around the\n            <jats:italic>mecA</jats:italic>\n            gene, and the presence of cassette chromosome recombinase (\n            <jats:italic>ccr</jats:italic>\n            ) genes responsible for the movements of SCC\n            <jats:italic>mec</jats:italic>\n            . The elements, therefore, were considered to comprise the SCC\n            <jats:italic>mec</jats:italic>\n            family of staphylococcal mobile genetic elements together with the previously identified SCC\n            <jats:italic>mec</jats:italic>\n            . Among 38 epidemic MRSA strains isolated in 20 countries, 34 were shown to possess one of the three typical SCC\n            <jats:italic>mec</jats:italic>\n            elements on the chromosome. Our findings indicated that there are at least three distinct MRSA clones in the world with different types of SCC\n            <jats:italic>mec</jats:italic>\n            in their chromosome.\n          </jats:p>","is_dataset_classified":null,"base_score":6.8658910748834385,"endowment":6.8658910748834385,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11302791","pmcid":"PMC90469","openalex_id":"https://openalex.org/W2161836519","authors":[],"funders":[],"total_grants":0,"fwci":17.2726,"citation_percentile":0.99689872,"influential_citations":0,"citation_trend":[{"year":2012,"count":41},{"year":2013,"count":46},{"year":2014,"count":53},{"year":2015,"count":42},{"year":2016,"count":35},{"year":2017,"count":24},{"year":2018,"count":18},{"year":2019,"count":40},{"year":2020,"count":20},{"year":2021,"count":22},{"year":2022,"count":27},{"year":2023,"count":25},{"year":2024,"count":17},{"year":2025,"count":11},{"year":2026,"count":11}],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/90469","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/90469","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.45.5.1323-1336.2001","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.45.5.1323-1336.2001","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11302791","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC90469","host_type":"repository"}],"fields_of_study":["Antimicrobial Resistance in Staphylococcus","RNA and protein synthesis mechanisms","Bacterial Genetics and Biotechnology"],"mesh_terms":["Amino Acid Sequence","Bacterial Proteins","Base Sequence","Muramoylpentapeptide Carboxypeptidase","Carrier Proteins","Chromosomes, Bacterial","Hexosyltransferases","Humans","Molecular Sequence Data","Peptidyl Transferases","Phylogeny","Plant Proteins","Sequence Homology, Nucleic Acid","Staphylococcus aureus","Restriction Mapping","Methicillin Resistance","Mutagenesis, Insertional","Sequence Homology, Amino Acid","Evolution, Molecular","Penicillin-Binding Proteins"],"keywords":["SCCmec","Mobile genetic elements","Biology","Genetics","Chromosome","Staphylococcus aureus","Recombinase","Gene","Microbiology","Methicillin-resistant Staphylococcus aureus","Genome","Bacteria"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T01:42:33.839564Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}