{"doi":"10.1128/aac.45.3.949-951.2001","title":"Comparison of Efficacies of Cysteine Protease Inhibitors against Five Strains of\n            <i>Plasmodium falciparum</i>","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Falcipain-2, a cysteine protease and essential hemoglobinase of\n            <jats:italic>Plasmodium falciparum</jats:italic>\n            , is a potential antimalarial drug target. We compared the falcipain-2 sequences and sensitivities to cysteine protease inhibitors of five parasite strains that differ markedly in sensitivity to established antimalarial drugs. The sequence of falcipain-2 was highly conserved, and the sensitivities of all of the strains to falcipain-2 inhibitors were very similar. Thus, cross-resistance between cysteine protease inhibitors and other antimalarial agents is not expected in parasites that are now circulating and falcipain-2 remains a promising chemotherapeutic target.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2001,"id":20363,"datarank":2.8970316629052473,"base_score":4.499809670330265,"endowment":4.499809670330265,"self_citation_contribution":0.6749714505495399,"citation_network_contribution":2.2220602123557076,"self_endowment_contribution":0.6749714505495399,"citer_contribution":2.2220602123557076,"corpus_percentile":null,"corpus_rank":null,"citation_count":89,"citer_count":48,"citers_with_citation_signal":43,"citers_with_endowment":43,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":134160,"name":"Philip J. Rosenthal","orcid":null,"position":1,"is_corresponding":false},{"id":134861,"name":"Ajay Singh","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.499809670330265,"endowment":4.499809670330265,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11181388","pmcid":"PMC90401","openalex_id":"https://openalex.org/W1988598700","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"AI35800","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI035800","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R29 AI035800","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R56 AI035800","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"P41 RR001081","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"RR01081","title":null}],"total_grants":6,"fwci":6.1606,"citation_percentile":0.9575252,"influential_citations":7,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":6},{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":3},{"year":2017,"count":5},{"year":2018,"count":1},{"year":2019,"count":3},{"year":2020,"count":4},{"year":2021,"count":5},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":5},{"year":2025,"count":3}],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/90401","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc90401?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/90401","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.45.3.949-951.2001","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.45.3.949-951.2001","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11181388","host_type":"repository"}],"fields_of_study":["Malaria Research and Control","Research on Leishmaniasis Studies","Trypanosoma species research and implications","Medicine","Biology","Animals","Antimalarials","Cysteine Endopeptidases","Cysteine Proteinase Inhibitors","DNA, Protozoan","Drug Evaluation, Preclinical","Molecular Sequence Data","Plasmodium falciparum"],"mesh_terms":["Animals","Antimalarials","Cysteine Endopeptidases","Drug Evaluation, Preclinical","Molecular Sequence Data","Plasmodium falciparum","Cysteine Proteinase Inhibitors","DNA, Protozoan"],"keywords":["Plasmodium falciparum","Cysteine protease","Protease","Biology","Cysteine","Cysteine Proteinase Inhibitors","Microbiology","Enzyme","Virology","Malaria","Biochemistry","Immunology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.14880873.v1","title":"Additional file 1 of Identification of 3,3′-O-dimethylellagic acid and apigenin as the main antiplasmodial constituents of Endodesmia calophylloides Benth and Hymenostegia afzelii (Oliver.) 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