{"doi":"10.1128/aac.45.1.349-352.2001","title":"Clinical Isolate of Vancomycin-Heterointermediate\n Staphylococcus aureus\n Susceptible to Methicillin and In Vitro Selection of a Vancomycin-Resistant Derivative","abstract":"ABSTRACT\n \n A\n Staphylococcus aureus\n strain with low-level heteroresistance to vancomycin (designated MER) but susceptible to methicillin was isolated from an outpatient with conjunctivitis who did not receive any glycopeptide antibiotics. Incubation of the parent strain, MER, with increasing concentrations of vancomycin led to rapid selection of a stable progeny homogeneously resistant to vancomycin. Electron micrographs of strain MER showed enhanced cell wall thickness and abnormal septations typically seen with methicillin-resistant\n S. aureus\n having intermediate susceptibility to vancomycin.\n ","journal":"Antimicrobial Agents and Chemotherapy","year":2001,"id":616113,"datarank":0.6190701577567639,"base_score":4.127134385045092,"endowment":4.127134385045092,"self_citation_contribution":0.6190701577567639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6190701577567639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1588303,"name":"Marie-Elisabeth Reverdy","orcid":null,"position":1,"is_corresponding":false},{"id":1588304,"name":"Chantal Nervi","orcid":null,"position":2,"is_corresponding":false},{"id":1588306,"name":"Martine Rougier","orcid":null,"position":3,"is_corresponding":false},{"id":1588308,"name":"Anne Bolmström","orcid":null,"position":4,"is_corresponding":false},{"id":1588310,"name":"François Vandenesch","orcid":null,"position":5,"is_corresponding":false},{"id":1588312,"name":"Jerome Etienne","orcid":null,"position":6,"is_corresponding":false},{"id":1588302,"name":"Sophie Bobin-Dubreux","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical Isolate of Vancomycin-Heterointermediate\n Staphylococcus aureus\n Susceptible to Methicillin and In Vitro Selection of a Vancomycin-Resistant Derivative","abstract":"ABSTRACT\n \n A\n Staphylococcus aureus\n strain with low-level heteroresistance to vancomycin (designated MER) but susceptible to methicillin was isolated from an outpatient with conjunctivitis who did not receive any glycopeptide antibiotics. Incubation of the parent strain, MER, with increasing concentrations of vancomycin led to rapid selection of a stable progeny homogeneously resistant to vancomycin. Electron micrographs of strain MER showed enhanced cell wall thickness and abnormal septations typically seen with methicillin-resistant\n S. aureus\n having intermediate susceptibility to vancomycin.\n ","is_dataset_classified":null,"base_score":4.127134385045092,"endowment":4.127134385045092,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11120996","pmcid":"PMC90291","openalex_id":"https://openalex.org/W2099065614","authors":[],"funders":[],"total_grants":0,"fwci":4.1509,"citation_percentile":0.94596298,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":3},{"year":2015,"count":1},{"year":2017,"count":1},{"year":2020,"count":1}],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/90291","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/90291","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.45.1.349-352.2001","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.45.1.349-352.2001","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11120996","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC90291","host_type":"repository"}],"fields_of_study":["Antimicrobial Resistance in Staphylococcus","Bacterial Identification and Susceptibility Testing","Bacterial biofilms and quorum sensing","Adult","Anti-Bacterial Agents","Conjunctivitis","Female","Humans","Methicillin","Penicillins","Staphylococcal Infections","Staphylococcus aureus","Vancomycin","Vancomycin Resistance"],"mesh_terms":["Adult","Anti-Bacterial Agents","Conjunctivitis","Female","Humans","Methicillin","Penicillins","Staphylococcal Infections","Staphylococcus aureus","Vancomycin","Vancomycin Resistance"],"keywords":["Vancomycin","Staphylococcus aureus","Glycopeptide","Microbiology","Antibiotics","Strain (injury)","Micrococcaceae","Methicillin-resistant Staphylococcus aureus","Biology","Antibacterial agent","Bacteria","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T21:59:26.645111Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}