{"doi":"10.1128/aac.43.3.711","title":"Genetic Evidence that InhA of\n            <i>Mycobacterium smegmatis</i>\n            Is a Target for Triclosan","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Three\n            <jats:italic>Mycobacterium smegmatis</jats:italic>\n            mutants selected for resistance to triclosan each had a different mutation in InhA, an enoyl reductase involved in fatty acid synthesis. Two expressed some isoniazid resistance. A mutation originally selected on isoniazid also mediated triclosan resistance, as did the wild-type\n            <jats:italic>inhA</jats:italic>\n            gene on a multicopy plasmid. Replacement of the mutant chromosomal\n            <jats:italic>inhA</jats:italic>\n            genes with wild-type\n            <jats:italic>inhA</jats:italic>\n            eliminated resistance. These results suggest that\n            <jats:italic>M. smegmatis</jats:italic>\n            InhA, like its\n            <jats:italic>Escherichia coli</jats:italic>\n            homolog FabI, is a target for triclosan.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":1999,"id":682890,"datarank":0.8048964022532777,"base_score":5.365976015021851,"endowment":5.365976015021851,"self_citation_contribution":0.8048964022532777,"citation_network_contribution":0.0,"self_endowment_contribution":0.8048964022532777,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":213,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":404817,"name":"Patrick F. McDermott","orcid":"0000-0003-1868-8096","position":1,"is_corresponding":false},{"id":1109943,"name":"Stuart B. Levy","orcid":"0000-0002-8845-8870","position":2,"is_corresponding":false},{"id":1783961,"name":"Laura M. McMurry","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genetic Evidence that InhA of <i>Mycobacterium smegmatis</i> Is a Target for Triclosan","abstract":"Three Mycobacterium smegmatis mutants selected for resistance to triclosan each had a different mutation in InhA, an enoyl reductase involved in fatty acid synthesis. Two expressed some isoniazid resistance. A mutation originally selected on isoniazid also mediated triclosan resistance, as did the wild-type inhA gene on a multicopy plasmid. Replacement of the mutant chromosomal inhA genes with wild-type inhA eliminated resistance. These results suggest that M. smegmatis InhA, like its Escherichia coli homolog FabI, is a target for triclosan.","is_dataset_classified":null,"base_score":5.365976015021851,"endowment":5.365976015021851,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10049298","pmcid":"PMC89191","openalex_id":"https://openalex.org/W2171243523","authors":[],"funders":[],"total_grants":0,"fwci":8.7569,"citation_percentile":0.98500424,"influential_citations":0,"citation_trend":[{"year":2012,"count":11},{"year":2013,"count":7},{"year":2014,"count":4},{"year":2015,"count":6},{"year":2016,"count":6},{"year":2017,"count":9},{"year":2018,"count":7},{"year":2019,"count":7},{"year":2020,"count":7},{"year":2021,"count":3},{"year":2022,"count":5},{"year":2023,"count":5},{"year":2024,"count":1},{"year":2025,"count":3}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://aac.asm.org/content/aac/43/3/711.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/43/3/711.full.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.43.3.711","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10049298","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/89191","host_type":"repository"}],"fields_of_study":["Tuberculosis Research and Epidemiology","Mycobacterium research and diagnosis","Antibiotic Resistance in Bacteria","Anti-Infective Agents, Local","Bacterial Proteins","Humans","Isoniazid","Mutation","Mycobacterium smegmatis","Oxidoreductases","Triclosan"],"mesh_terms":["Anti-Infective Agents, Local","Bacterial Proteins","Humans","Isoniazid","Mutation","Oxidoreductases","Triclosan","Mycobacterium smegmatis"],"keywords":["INHA","Mycobacterium smegmatis","Triclosan","Mutant","Biology","Microbiology","Isoniazid","Escherichia coli","Wild type","Plasmid","Genetics","Gene","Mycobacterium tuberculosis","Medicine","Tuberculosis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T21:38:28.046967Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}