{"doi":"10.1128/aac.43.3.647","title":"A Multiple Drug Interaction Study of Stavudine with Agents for Opportunistic Infections in Human Immunodeficiency Virus-Infected Patients","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The effects of multiple opportunistic infection medications on stavudine pharmacokinetics were evaluated. Ten patients with CD4 counts of less than 200 cells/mm\n            <jats:sup>3</jats:sup>\n            received stavudine (40 mg twice daily) in combination with one to three other drugs used to treat opportunistic infections. Serial blood samples for stavudine concentrations were collected after 1 week of therapy on each regimen and assayed for stavudine by using a validated high-pressure liquid chromatography method. Although the maximum concentration of drug in serum was significantly decreased when the drug was given in combination with three opportunistic infection medications, the area under the concentration-time curve did not significantly differ across various treatment regimens. Stavudine exposure was not significantly altered by multiple concomitant medications. Side effects were minor throughout the 3-month study period. The tolerability of stavudine, combined with its lack of drug interactions, makes it an attractive agent for use as part of a combination regimen.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":1999,"id":675972,"datarank":1.2259638266055415,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.8100755182695741,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.8100755182695741,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":14,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1048373,"name":"Grace Kelly","orcid":"0000-0003-4688-537X","position":1,"is_corresponding":false},{"id":1766227,"name":"Robert E. Walker","orcid":null,"position":2,"is_corresponding":false},{"id":1766229,"name":"Joseph Kovacs","orcid":null,"position":3,"is_corresponding":false},{"id":12091,"name":"Judith Falloon","orcid":"0000-0002-6298-8953","position":4,"is_corresponding":false},{"id":104996,"name":"Richard T. Davey","orcid":"0000-0002-3992-5524","position":5,"is_corresponding":false},{"id":1766231,"name":"Sangita Raje","orcid":null,"position":6,"is_corresponding":false},{"id":246186,"name":"Henry Masur","orcid":"0000-0002-3688-021X","position":7,"is_corresponding":false},{"id":611810,"name":"Michael A. Polis","orcid":"0000-0002-9151-2268","position":8,"is_corresponding":false},{"id":1621633,"name":"Stephen C. Piscitelli","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Multiple Drug Interaction Study of Stavudine with Agents for Opportunistic Infections in Human Immunodeficiency Virus-Infected Patients","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The effects of multiple opportunistic infection medications on stavudine pharmacokinetics were evaluated. Ten patients with CD4 counts of less than 200 cells/mm\n            <jats:sup>3</jats:sup>\n            received stavudine (40 mg twice daily) in combination with one to three other drugs used to treat opportunistic infections. Serial blood samples for stavudine concentrations were collected after 1 week of therapy on each regimen and assayed for stavudine by using a validated high-pressure liquid chromatography method. Although the maximum concentration of drug in serum was significantly decreased when the drug was given in combination with three opportunistic infection medications, the area under the concentration-time curve did not significantly differ across various treatment regimens. Stavudine exposure was not significantly altered by multiple concomitant medications. Side effects were minor throughout the 3-month study period. The tolerability of stavudine, combined with its lack of drug interactions, makes it an attractive agent for use as part of a combination regimen.\n          </jats:p>","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10049281","pmcid":"PMC89174","openalex_id":"https://openalex.org/W1794769864","authors":[],"funders":[],"total_grants":0,"fwci":1.0942,"citation_percentile":0.76061521,"influential_citations":0,"citation_trend":[{"year":2016,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://aac.asm.org/content/aac/43/3/647.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/43/3/647.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.43.3.647","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.43.3.647","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10049281","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC89174","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/89174","host_type":"repository"}],"fields_of_study":["HIV/AIDS drug development and treatment","Pneumocystis jirovecii pneumonia detection and treatment","Tuberculosis Research and Epidemiology"],"mesh_terms":["Adult","Anti-Infective Agents","Drug Interactions","Female","Humans","Male","Patient Compliance","HIV Infections","AIDS-Related Opportunistic Infections","Stavudine","Anti-HIV Agents","Area Under Curve"],"keywords":["Stavudine","Regimen","Tolerability","Drug","Pharmacokinetics","Pharmacology","Medicine","Concomitant","Internal medicine","Human immunodeficiency virus (HIV)","Immunology","Zidovudine","Viral disease","Adverse effect"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T01:56:13.312104Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}