{"doi":"10.1128/aac.42.2.468","title":"Critical Importance of In Vivo Amoxicillin and Cefotaxime Concentrations for Synergy in Treatment of Experimental\n            <i>Enterococcus faecalis</i>\n            Endocarditis","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The synergy between amoxicillin and cefotaxime against two strains of\n            <jats:italic>Enterococcus faecalis</jats:italic>\n            (JH2-2 and 6370) in vitro and in rabbit endocarditis was investigated. In vitro synergy was obtained only when amoxicillin concentrations were below the MBC and when cefotaxime concentrations were above 1 μg/ml. No synergy was observed in vivo, because of the short period of time during which these pharmacologic requirements were achieved.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":1998,"id":681083,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1779472,"name":"Jean-Luc Mainardi","orcid":null,"position":1,"is_corresponding":false},{"id":1779474,"name":"Catherine Cuvelier","orcid":null,"position":2,"is_corresponding":false},{"id":1779476,"name":"Sophie Dautrey","orcid":null,"position":3,"is_corresponding":false},{"id":1523150,"name":"Robert Farinotti","orcid":null,"position":4,"is_corresponding":false},{"id":1779479,"name":"Bruno Fantin","orcid":null,"position":5,"is_corresponding":false},{"id":1779480,"name":"Claude Carbon","orcid":null,"position":6,"is_corresponding":false},{"id":1779471,"name":"Olivier Join-Lambert","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Critical Importance of In Vivo Amoxicillin and Cefotaxime Concentrations for Synergy in Treatment of Experimental\n            <i>Enterococcus faecalis</i>\n            Endocarditis","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The synergy between amoxicillin and cefotaxime against two strains of\n            <jats:italic>Enterococcus faecalis</jats:italic>\n            (JH2-2 and 6370) in vitro and in rabbit endocarditis was investigated. In vitro synergy was obtained only when amoxicillin concentrations were below the MBC and when cefotaxime concentrations were above 1 μg/ml. No synergy was observed in vivo, because of the short period of time during which these pharmacologic requirements were achieved.\n          </jats:p>","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9527811","pmcid":"PMC105439","openalex_id":"https://openalex.org/W2103454252","authors":[],"funders":[],"total_grants":0,"fwci":0.6327,"citation_percentile":0.71562715,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://aac.asm.org/content/aac/42/2/468.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/42/2/468.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.42.2.468","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.42.2.468","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9527811","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/105439","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC105439","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC105439/pdf/ac000468.pdf","host_type":"repository"}],"fields_of_study":["Antimicrobial Resistance in Staphylococcus","Antibiotics Pharmacokinetics and Efficacy","Infective Endocarditis Diagnosis and Management","Amoxicillin","Animals","Cefotaxime","Drug Synergism","Drug Therapy, Combination","Endocarditis, Bacterial","Enterococcus faecalis","Gram-Positive Bacterial Infections","Rabbits"],"mesh_terms":["Amoxicillin","Animals","Cefotaxime","Drug Synergism","Drug Therapy, Combination","Endocarditis, Bacterial","Rabbits","Enterococcus faecalis","Gram-Positive Bacterial Infections"],"keywords":["Cefotaxime","Enterococcus faecalis","Amoxicillin","In vivo","Microbiology","Endocarditis","In vitro","Antibacterial agent","Antibiotics","Enterococcus","Chemistry","Medicine","Pharmacology","Biology","Surgery","Bacteria","Biochemistry","Staphylococcus aureus","Biotechnology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T16:53:45.820804Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}