{"doi":"10.1128/aac.3.5.638","title":"Mechanisms of R Factor R931 and Chromosomal Tetracycline Resistance in\n            <i>Pseudomonas aeruginosa</i>","abstract":"<jats:p>\n            The mechanism of tetracycline resistance mediated by R931 (a\n            <jats:italic>Pseudomonas aeruginosa</jats:italic>\n            R factor not yet successfully transferred to\n            <jats:italic>Escherichia coli</jats:italic>\n            recipients) was examined. In strain 931 (R931) (minimal inhibitory concentration [MIC] 200 μg/ml) significant tetracycline uptake did not occur until 100 μg of tetracycline per ml was included in uptake studies. The introduction of R931 into strain 280 resulted in a significant decline in\n            <jats:sup>3</jats:sup>\n            H-tetracycline uptake. In both strains 931 (R931) and 280 (R931), a further reduction in tetracycline uptake resulted from pre-incubation with 1 μg of tetracycline per ml. Tetracycline resistance in R\n            <jats:sup>−</jats:sup>\n            <jats:italic>P. aeruginosa</jats:italic>\n            strains 1731, 1885, and 494, considered to be of chromosomal origin, was associated with a lack of tetracycline uptake until the MIC of the strain was obtained. No evidence of tetracycline inactivation or ribosomal resistance was detected in R\n            <jats:sup>−</jats:sup>\n            or R\n            <jats:sup>+</jats:sup>\n            strains. The MIC for R\n            <jats:sup>−</jats:sup>\n            strains was generally about 25 μg/ml and that for R\n            <jats:sup>+</jats:sup>\n            strains was 75 to 200 μg/ml.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":1973,"id":629777,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1631168,"name":"L. E. Bryan","orcid":null,"position":1,"is_corresponding":false},{"id":1631167,"name":"J. T. Tseng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mechanisms of R Factor R931 and Chromosomal Tetracycline Resistance in\n            <i>Pseudomonas aeruginosa</i>","abstract":"<jats:p>\n            The mechanism of tetracycline resistance mediated by R931 (a\n            <jats:italic>Pseudomonas aeruginosa</jats:italic>\n            R factor not yet successfully transferred to\n            <jats:italic>Escherichia coli</jats:italic>\n            recipients) was examined. In strain 931 (R931) (minimal inhibitory concentration [MIC] 200 μg/ml) significant tetracycline uptake did not occur until 100 μg of tetracycline per ml was included in uptake studies. The introduction of R931 into strain 280 resulted in a significant decline in\n            <jats:sup>3</jats:sup>\n            H-tetracycline uptake. In both strains 931 (R931) and 280 (R931), a further reduction in tetracycline uptake resulted from pre-incubation with 1 μg of tetracycline per ml. Tetracycline resistance in R\n            <jats:sup>−</jats:sup>\n            <jats:italic>P. aeruginosa</jats:italic>\n            strains 1731, 1885, and 494, considered to be of chromosomal origin, was associated with a lack of tetracycline uptake until the MIC of the strain was obtained. No evidence of tetracycline inactivation or ribosomal resistance was detected in R\n            <jats:sup>−</jats:sup>\n            or R\n            <jats:sup>+</jats:sup>\n            strains. The MIC for R\n            <jats:sup>−</jats:sup>\n            strains was generally about 25 μg/ml and that for R\n            <jats:sup>+</jats:sup>\n            strains was 75 to 200 μg/ml.\n          </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4208296","pmcid":"PMC444469","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/444469","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.3.5.638","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Pseudomonas aeruginosa","Carbon Radioisotopes","Tetracycline","Microbial Sensitivity Tests","Drug Resistance, Microbial","Extrachromosomal Inheritance"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T19:38:40.787567Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}