{"doi":"10.1128/aac.15.1.123","title":"Production of β-Lactamase by Non-\n            <i>Streptomyces Actinomycetales</i>","abstract":"<jats:p>\n            Supernatants and whole cells from fermentation broths of\n            <jats:italic>Micromonospora, Nocardia, Oerskovia</jats:italic>\n            , and other genera of the\n            <jats:italic>Actinomycetales</jats:italic>\n            were examined for the presence of β-lactamase activity by using the chromogenic cephalosporin 87/312. Nearly 60% of the 250 isolates examined produced detectable levels of β-lactamase. All enzyme preparations were active over a range of pH values from 6.5 to 8.2, with maximum activity occurring between 7.0 and 7.8. The preparations varied in their stability at 60°C. An examination of selected enzyme preparations revealed a similarity between substrate specificities of the non-\n            <jats:italic>Streptomyces Actinomycetales</jats:italic>\n            and gram-negative-bacterial β-lactamases.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":1979,"id":38849,"datarank":0.8702297846486615,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.5248420206995547,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.5248420206995547,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":9,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":192042,"name":"Surya P. Schwartz","orcid":null,"position":1,"is_corresponding":false},{"id":192041,"name":"Jeffrey L. Schwartz","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"311614","pmcid":"PMC352610","openalex_id":"https://openalex.org/W2040260355","authors":[],"funders":[],"total_grants":0,"fwci":0.5821,"citation_percentile":0.62763251,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352610","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc352610?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352610","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.15.1.123","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.15.1.123","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/311614","host_type":"repository"}],"fields_of_study":["Enzyme function and inhibition","Microbial Natural Products and Biosynthesis","Synthesis and Catalytic Reactions","Biology","Actinomycetales","Fermentation","Micromonospora","Nocardia","beta-Lactamases"],"mesh_terms":["Actinomycetales","beta-Lactamases","Fermentation","Micromonospora","Nocardia"],"keywords":["Actinomycetales","Micromonospora","Nocardia","Microbiology","Biology","Streptomycetaceae","Streptomyces","Nocardiaceae","Cephalosporin","Bacteria","Enzyme","Antibiotics","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-11T06:51:05.602237Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}