{"doi":"10.1128/aac.05065-14","title":"Predominance of KPC-3 in a Survey for Carbapenemase-Producing Enterobacteriaceae in Portugal","abstract":"ABSTRACT\n \n Among the 2,105\n Enterobacteriaceae\n tested in a survey done in Portugal, 165 were nonsusceptible to carbapenems, from which 35 (26\n Klebsiella pneumoniae\n , 3\n Escherichia coli\n , 2\n Enterobacter aerogenes\n , and 3\n Enterobacter cloacae\n isolates and 1\n Klebsiella oxytoca\n isolate) were confirmed to be carbapenemase producers by the presence of 30\n Tn\n 4401d-\n bla\n KPC-3\n , 4\n intI\n 3-\n bla\n GES-5\n , and one\n intI\n 1-\n bla\n VIM-2\n gene, alone or in combination with other\n bla\n genes. The dissemination of\n bla\n KPC-3\n gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination.\n ","journal":"Antimicrobial Agents and Chemotherapy","year":2015,"id":639992,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1663169,"name":"Eugénia Ferreira","orcid":null,"position":1,"is_corresponding":false},{"id":40083,"name":"Joana Almeida","orcid":null,"position":2,"is_corresponding":false},{"id":1663170,"name":"Stephanie Barbosa","orcid":null,"position":3,"is_corresponding":false},{"id":1663171,"name":"Constança Simões","orcid":null,"position":4,"is_corresponding":false},{"id":232761,"name":"Robert A. Bonomo","orcid":"0000-0002-3299-894X","position":6,"is_corresponding":false},{"id":1663172,"name":"Manuela Caniça","orcid":null,"position":7,"is_corresponding":false},{"id":1663168,"name":"Vera Manageiro","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Predominance of KPC-3 in a Survey for Carbapenemase-Producing Enterobacteriaceae in Portugal","abstract":"ABSTRACT\n \n Among the 2,105\n Enterobacteriaceae\n tested in a survey done in Portugal, 165 were nonsusceptible to carbapenems, from which 35 (26\n Klebsiella pneumoniae\n , 3\n Escherichia coli\n , 2\n Enterobacter aerogenes\n , and 3\n Enterobacter cloacae\n isolates and 1\n Klebsiella oxytoca\n isolate) were confirmed to be carbapenemase producers by the presence of 30\n Tn\n 4401d-\n bla\n KPC-3\n , 4\n intI\n 3-\n bla\n GES-5\n , and one\n intI\n 1-\n bla\n VIM-2\n gene, alone or in combination with other\n bla\n genes. The dissemination of\n bla\n KPC-3\n gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination.\n ","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25779587","pmcid":"PMC4432220","openalex_id":"https://openalex.org/W2101500984","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI100560","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI063517","title":null}],"total_grants":2,"fwci":1.6819,"citation_percentile":0.8251382,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":7},{"year":2017,"count":5},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":8},{"year":2021,"count":5},{"year":2022,"count":6},{"year":2024,"count":5}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://aac.asm.org/content/aac/59/6/3588.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/59/6/3588.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.05065-14","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.05065-14","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25779587","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4432220","host_type":"repository"},{"url":"http://hdl.handle.net/10400.18/3720","host_type":"repository"}],"fields_of_study":["Antibiotic Resistance in Bacteria","Pharmaceutical and Antibiotic Environmental Impacts","Enterobacteriaceae and Cronobacter Research"],"mesh_terms":["Bacterial Proteins","beta-Lactamases","Enterobacteriaceae","Escherichia coli","Klebsiella pneumoniae","Microbial Sensitivity Tests","Plasmids","Portugal","Enterobacter aerogenes","Klebsiella oxytoca"],"keywords":["Enterobacter cloacae","Enterobacter aerogenes","Klebsiella oxytoca","Klebsiella pneumoniae","Enterobacteriaceae","Microbiology","Biology","Plasmid","Enterobacter","Escherichia coli","Gene","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T05:45:54.882045Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}