{"doi":"10.1128/aac.02360-17","title":"The Clarithromycin Susceptibility Genotype Affects the Treatment Outcome of Patients with Mycobacterium abscessus Lung Disease","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Mycobacterium abscessus</jats:named-content>\n            accounts for a large proportion of lung disease cases caused by rapidly growing mycobacteria. The association between clarithromycin sensitivity and treatment outcome is clear. However,\n            <jats:named-content content-type=\"genus-species\">M. abscessus</jats:named-content>\n            culture and antibiotic susceptibility testing are time-consuming. Clarithromycin susceptibility genotyping offers an alternate, rapid approach to predicting the efficacy of clarithromycin-based antibiotic therapy.\n            <jats:named-content content-type=\"genus-species\">M. abscessus</jats:named-content>\n            lung disease patients were divided into two groups based upon the clarithromycin susceptibility genotype of the organism isolated. A retrospective analysis was conducted to compare the clinical features, microbiological characteristics, and treatment outcomes of the two groups. Several other potential predictors of the response to treatment were also assessed. Sixty-nine patients were enrolled in the clarithromycin-resistant genotype group, which included 5 infected with\n            <jats:italic>rrl</jats:italic>\n            2058-2059 mutants and 64 infected with\n            <jats:italic>erm</jats:italic>\n            (41)T28-type\n            <jats:named-content content-type=\"genus-species\">M. abscessus</jats:named-content>\n            ; 31 were in the clarithromycin-sensitive group, i.e., 6 and 25 patients infected with genotypes\n            <jats:italic>erm</jats:italic>\n            (41)C28 and\n            <jats:italic>erm</jats:italic>\n            (41) M type, respectively. The results showed that lung disease patients infected with clarithromycin-sensitive and -resistant\n            <jats:named-content content-type=\"genus-species\">M. abscessus</jats:named-content>\n            genotypes differed significantly in clarithromycin-based combination treatment outcomes. Patients infected with the clarithromycin-sensitive genotype exhibited higher initial and final sputum-negative conversion and radiological improvement rates and better therapeutic outcomes. Multivariate analysis demonstrated that genotyping was a reliable and, more importantly, rapid means of predicting the efficacy of clarithromycin-based antibiotic treatment for\n            <jats:named-content content-type=\"genus-species\">M. abscessus</jats:named-content>\n            lung disease.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2018,"id":647864,"datarank":2.145935740712459,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":1.6084078999440423,"self_endowment_contribution":0.5375278407684165,"citer_contribution":1.6084078999440423,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":29,"citers_with_citation_signal":24,"citers_with_endowment":24,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1203887,"name":"Haiqing Chu","orcid":"0000-0002-9168-7295","position":1,"is_corresponding":false},{"id":1337580,"name":"Meiping Ye","orcid":null,"position":2,"is_corresponding":false},{"id":1392788,"name":"Zhemin Zhang","orcid":"0000-0003-0135-4970","position":3,"is_corresponding":false},{"id":292936,"name":"Bing Li","orcid":"0009-0008-6080-2861","position":4,"is_corresponding":false},{"id":656753,"name":"Shiyi Yang","orcid":"0000-0002-7276-6940","position":5,"is_corresponding":false},{"id":586091,"name":"Wei Ma","orcid":"0000-0003-1305-3980","position":6,"is_corresponding":false},{"id":344760,"name":"Fangyou Yu","orcid":"0000-0003-4924-2484","position":7,"is_corresponding":false},{"id":1404187,"name":"Qi Guo","orcid":"0000-0001-9243-9210","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Clarithromycin Susceptibility Genotype Affects the Treatment Outcome of Patients with Mycobacterium abscessus Lung Disease","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Mycobacterium abscessus</jats:named-content>\n            accounts for a large proportion of lung disease cases caused by rapidly growing mycobacteria. The association between clarithromycin sensitivity and treatment outcome is clear. However,\n            <jats:named-content content-type=\"genus-species\">M. abscessus</jats:named-content>\n            culture and antibiotic susceptibility testing are time-consuming. Clarithromycin susceptibility genotyping offers an alternate, rapid approach to predicting the efficacy of clarithromycin-based antibiotic therapy.\n            <jats:named-content content-type=\"genus-species\">M. abscessus</jats:named-content>\n            lung disease patients were divided into two groups based upon the clarithromycin susceptibility genotype of the organism isolated. A retrospective analysis was conducted to compare the clinical features, microbiological characteristics, and treatment outcomes of the two groups. Several other potential predictors of the response to treatment were also assessed. Sixty-nine patients were enrolled in the clarithromycin-resistant genotype group, which included 5 infected with\n            <jats:italic>rrl</jats:italic>\n            2058-2059 mutants and 64 infected with\n            <jats:italic>erm</jats:italic>\n            (41)T28-type\n            <jats:named-content content-type=\"genus-species\">M. abscessus</jats:named-content>\n            ; 31 were in the clarithromycin-sensitive group, i.e., 6 and 25 patients infected with genotypes\n            <jats:italic>erm</jats:italic>\n            (41)C28 and\n            <jats:italic>erm</jats:italic>\n            (41) M type, respectively. The results showed that lung disease patients infected with clarithromycin-sensitive and -resistant\n            <jats:named-content content-type=\"genus-species\">M. abscessus</jats:named-content>\n            genotypes differed significantly in clarithromycin-based combination treatment outcomes. Patients infected with the clarithromycin-sensitive genotype exhibited higher initial and final sputum-negative conversion and radiological improvement rates and better therapeutic outcomes. Multivariate analysis demonstrated that genotyping was a reliable and, more importantly, rapid means of predicting the efficacy of clarithromycin-based antibiotic treatment for\n            <jats:named-content content-type=\"genus-species\">M. abscessus</jats:named-content>\n            lung disease.\n          </jats:p>","is_dataset_classified":null,"base_score":3.58351893845611,"endowment":3.58351893845611,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29483126","pmcid":"PMC5923093","openalex_id":"https://openalex.org/W2789338299","authors":[],"funders":[{"funder_name":"Medical Guide Program of Shanghai Science and Technology Committee","grant_id":"14411962900","title":null},{"funder_name":"Key Project of Shanghai Municipal Health and Family Planning Commission","grant_id":"201540367","title":null},{"funder_name":"Youth Project of Shanghai Municipal Health and Family Planning Commission","grant_id":"20164Y0230","title":null},{"funder_name":"New Frontier Technology Joint Project of Municipal Hospital, Shanghai Shenkang Hospital Develoment Center","grant_id":"SHDC12017113","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81672063","title":null}],"total_grants":5,"fwci":2.7044,"citation_percentile":0.90296029,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":4},{"year":2020,"count":5},{"year":2021,"count":8},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":4},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://aac.asm.org/content/aac/62/5/e02360-17.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/62/5/e02360-17.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.02360-17","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.02360-17","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29483126","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC5923093","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5923093","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5923093","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5923093?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Mycobacterium research and diagnosis","Tuberculosis Research and Epidemiology","Infectious Diseases and Mycology"],"mesh_terms":["Mycobacterium abscessus","Anti-Bacterial Agents","Genotype","Humans","Microbial Sensitivity Tests","Retrospective Studies","Clarithromycin"],"keywords":["Clarithromycin","Mycobacterium abscessus","Genotype","Medicine","Antibiotics","Internal medicine","Nontuberculous mycobacteria","Genotyping","Mycobacterium","Gastroenterology","Microbiology","Biology","Pathology","Tuberculosis","Lung disease","Treatment outcome"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"bioproject"},{"name":"gen"},{"name":"refseq"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T01:57:45.765472Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}