{"doi":"10.1128/aac.02339-21","title":"The Cationic Antimicrobial Peptide Activity of Lysozyme Reduces Viable <i>Enterococcus faecalis</i> Cells in Biofilms","abstract":"biofilms contained a higher percentage of dead cells by Live/Dead staining and were associated with more extracellular DNA. Heat-inactivated human lysozyme, which was devoid of muramidase activity, as well as the lysozyme-derived CAMP LP9 and the CAMP polymyxin B, decreased biofilm cell viability. These results are consistent with a model in which the CAMP activity, rather than the muramidase activity, of lysozyme causes lysis of E. faecalis biofilm cells despite them having an intact lysozyme resistance-inducing signaling pathway. Finally, lysozyme was also effective in reducing viable biofilm cells of several other E. faecalis strains, including the vancomycin-resistant strain V583 and multidrug-resistant strain MMH594. This study demonstrates the potential for lysozyme to be developed as a novel antibiofilm therapeutic.","journal":"Antimicrobial Agents and Chemotherapy","year":2022,"id":270087,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":934406,"name":"Jo-Ann Harris","orcid":null,"position":1,"is_corresponding":false},{"id":933784,"name":"Zahra Zubair-Nizami","orcid":"0009-0005-6078-880X","position":2,"is_corresponding":false},{"id":918073,"name":"Arielle J. Weinstein","orcid":null,"position":3,"is_corresponding":false},{"id":455814,"name":"Mohammad Roky","orcid":null,"position":4,"is_corresponding":false},{"id":424300,"name":"Kristi L. Frank","orcid":"0000-0003-0050-3380","position":5,"is_corresponding":false},{"id":425336,"name":"Candace N. Rouchon","orcid":null,"position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T00:27:26.772098Z","pmid":"35446133","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}