{"doi":"10.1128/aac.02205-18","title":"Impact of Preexisting Hepatitis C Virus Genotype 6 NS3, NS5A, and NS5B Polymorphisms on the<i>In Vitro</i>Potency of Direct-Acting Antiviral Agents","abstract":"<jats:p>HCV genotype 6 (GT-6) is found predominantly in East and Southeast Asia. Clinical studies have focused on patients infected with hepatitis C virus (HCV) GT-6a, where high sustained virologic response (SVR) rates to direct-acting antivirals (DAAs) have been achieved.</jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2019,"id":40107,"datarank":0.8735450385434103,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.5008090410752102,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.5008090410752102,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":11,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":61.25,"fair_percentile":92.70008795074759,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":195428,"name":"Joseph Ueland","orcid":null,"position":1,"is_corresponding":false},{"id":195429,"name":"Vincent Vellucci","orcid":null,"position":2,"is_corresponding":false},{"id":195430,"name":"Scott Bowden","orcid":null,"position":3,"is_corresponding":false},{"id":195431,"name":"William Sievert","orcid":null,"position":4,"is_corresponding":false},{"id":195432,"name":"Nannan Zhou","orcid":null,"position":5,"is_corresponding":false},{"id":195427,"name":"Fiona McPhee","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30718256","pmcid":"PMC6437522","openalex_id":"https://openalex.org/W2914046183","authors":[],"funders":[{"funder_name":"Bristol-Myers Squibb","grant_id":"","title":null}],"total_grants":1,"fwci":0.9409,"citation_percentile":0.73698564,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":3},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2025,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://aac.asm.org/content/aac/63/4/e02205-18.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/63/4/e02205-18.full.pdf","host_type":"BRONZE"},{"url":"https://aac.asm.org/content/aac/63/4/e02205-18.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.02205-18","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.02205-18","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30718256","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6437522","host_type":"repository"}],"fields_of_study":["Hepatitis C virus research","Hepatitis B Virus Studies","Liver Disease Diagnosis and Treatment","Biology","Medicine","Amino Acid Substitution","Antiviral Agents","Drug Resistance, Viral","Genotype","Hepacivirus","Hepatitis C","Humans","Phenotype","Polymorphism, Genetic","Treatment Failure","Viral Nonstructural Proteins"],"mesh_terms":["Antiviral Agents","Genotype","Hepatitis C","Humans","Phenotype","Polymorphism, Genetic","Hepacivirus","Treatment Failure","Viral Nonstructural Proteins","Amino Acid Substitution","Drug Resistance, Viral"],"keywords":["NS5A","NS5B","NS3","Virology","Hepatitis C virus","Genotype","Potency","Hepacivirus","Virus","Biology","Hepatitis C","In vitro","Gene","Genetics","Polymorphism","Resistance","HCV","Genotype 6","Sofosbuvir","Ombitasvir","Velpatasvir"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T01:26:40.668023Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":100.0,"fair_a":70.0,"fair_i":50.0,"fair_r":25.0,"fair_zscore":1.4508,"fair_rationale":{"fair_score":61.25,"has_llm":false,"dimensions":{"F":{"name":"Findable","score":100.0,"criteria":[{"key":"f_has_doi","label":"Has a persistent DOI","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"DOI present","rationale":null},{"key":"f_repository_presence","label":"Indexed in repositories / literature DBs","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"datacite=0, pmcid=True, pmid=True","rationale":null},{"key":"f_persistent_ids","label":"Resolvable scholarly identifiers (OpenAlex)","kind":"deterministic","weight":0.5,"fraction":1.0,"signal":"OpenAlex id present","rationale":null}]},"A":{"name":"Accessible","score":70.0,"criteria":[{"key":"a_open_access","label":"Open Access / files deposited","kind":"deterministic","weight":1.5,"fraction":0.5,"signal":"files/OA location present but not flagged OA","rationale":null},{"key":"a_retrievable","label":"Free full text retrievable","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"7 OA location(s)","rationale":null}]},"I":{"name":"Interoperable","score":50.0,"criteria":[{"key":"i_linked_data","label":"Linked datasets / DataCite relations","kind":"deterministic","weight":1.0,"fraction":0.0,"signal":"linked_datasets=0, datacite=0","rationale":null},{"key":"i_standard_ids","label":"References data via standard accessions","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"accessions=1, trials=0","rationale":null}]},"R":{"name":"Reusable","score":25.0,"criteria":[{"key":"r_license","label":"Clear, open reuse license","kind":"deterministic","weight":1.5,"fraction":0.5,"signal":"license present (https://journals.asm.org/non-commercial-tdm-license)","rationale":null},{"key":"r_downloads","label":"Demonstrated reuse (downloads)","kind":"deterministic","weight":0.5,"fraction":0.0,"signal":"downloads=0","rationale":null},{"key":"r_version","label":"Versioned / maintained","kind":"deterministic","weight":0.5,"fraction":0.0,"signal":"no version chain","rationale":null},{"key":"r_dataset","label":"Classified as a data resource","kind":"deterministic","weight":0.5,"fraction":0.0,"signal":"not a dataset","rationale":null}]}},"suggestions":["Link the underlying datasets via DOIs / DataCite relations.","Maintain explicit versioning for the dataset.","Make the paper/data Open Access or deposit the files in an open repository.","Attach a clear, open reuse license (e.g. CC-BY or CC0)."],"model":null,"agent_version":"fair_agent_v1","fulltext_source":"abstract_only"},"fair_model":null,"fair_agent_version":"fair_agent_v1","fair_fulltext_source":"abstract_only","fair_has_llm":false,"fair_computed_at":"2026-06-12T02:12:40.381919Z","clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}