{"doi":"10.1128/aac.02143-20","title":"Atypical Molecular Basis for Drug Resistance to Mitochondrial Function Inhibitors in Plasmodium falciparum","abstract":"The continued emergence of drug-resistant Plasmodium falciparum parasites hinders global attempts to eradicate malaria, emphasizing the need to identify new antimalarial drugs. Attractive targets for chemotherapeutic intervention are the cytochrome (cyt) bc 1 complex, which is an essential component of the mitochondrial electron transport chain (mtETC) required for ubiquinone recycling and mitochondrially localized dihydroorotate dehydrogenase (DHODH) critical for de novo pyrimidine synthesis.","journal":"Antimicrobial Agents and Chemotherapy","year":2021,"id":181773,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":576750,"name":"Joanne M. Morrisey","orcid":null,"position":1,"is_corresponding":false},{"id":453373,"name":"Michael W. Mather","orcid":"0000-0002-1062-0137","position":2,"is_corresponding":false},{"id":245295,"name":"Lindsey Orchard","orcid":"0000-0003-1295-3733","position":3,"is_corresponding":false},{"id":576259,"name":"Cuyler Luck","orcid":"0000-0002-1150-0057","position":4,"is_corresponding":false},{"id":576260,"name":"Martin J. Smilkstein","orcid":"0000-0002-4701-1722","position":5,"is_corresponding":false},{"id":381169,"name":"Michael K. Riscoe","orcid":"0000-0002-1343-5279","position":6,"is_corresponding":false},{"id":576261,"name":"Akhil B. Vaidya","orcid":"0000-0003-1063-5571","position":7,"is_corresponding":false},{"id":245298,"name":"Manuel Llinás","orcid":"0000-0002-6173-5882","position":8,"is_corresponding":false},{"id":245297,"name":"Heather J. Painter","orcid":"0000-0003-0264-4689","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T23:48:05.146883Z","pmid":"33361312","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}