{"doi":"10.1128/aac.02088-17","title":"Azole Resistance of Environmental and Clinical Aspergillus fumigatus Isolates from Switzerland","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus</jats:named-content>\n            is a ubiquitous opportunistic pathogen. This fungus can acquire resistance to azole antifungals due to mutations in the azole target (\n            <jats:italic>cyp51A</jats:italic>\n            ). Recently,\n            <jats:italic>cyp51A</jats:italic>\n            mutations typical for environmental azole resistance acquisition (for example, TR\n            <jats:sub>34</jats:sub>\n            /L98H) have been reported. These mutations can also be found in isolates recovered from patients. Environmental azole resistance acquisition has been reported on several continents. Here we describe, for the first time, the occurrence of azole-resistant\n            <jats:named-content content-type=\"genus-species\">A. fumigatus</jats:named-content>\n            isolates of environmental origin in Switzerland with\n            <jats:italic>cyp51A</jats:italic>\n            mutations, and we show that these isolates can also be recovered from a few patients. While the TR\n            <jats:sub>34</jats:sub>\n            /L98H mutation was dominant, a single azole-resistant isolate exhibited a\n            <jats:italic>cyp51A</jats:italic>\n            mutation (G54R) that was reported only for clinical isolates. In conclusion, our study demonstrates that azole resistance with an environmental signature is present in environments and patients of Swiss origin and that mutations believed to be unique to clinical settings are now also observed in the environment.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2018,"id":645193,"datarank":0.6166310796259968,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":0.0,"self_endowment_contribution":0.6166310796259968,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1679842,"name":"Jérôme Plojoux","orcid":null,"position":1,"is_corresponding":false},{"id":1166080,"name":"Katia Gindro","orcid":"0000-0003-4344-1853","position":2,"is_corresponding":false},{"id":1679843,"name":"Jacques Schrenzel","orcid":null,"position":3,"is_corresponding":false},{"id":1577246,"name":"Dominique Sanglard","orcid":"0000-0002-5244-4178","position":4,"is_corresponding":false},{"id":1679841,"name":"Arnaud Riat","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Azole Resistance of Environmental and Clinical Aspergillus fumigatus Isolates from Switzerland","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus</jats:named-content>\n            is a ubiquitous opportunistic pathogen. This fungus can acquire resistance to azole antifungals due to mutations in the azole target (\n            <jats:italic>cyp51A</jats:italic>\n            ). Recently,\n            <jats:italic>cyp51A</jats:italic>\n            mutations typical for environmental azole resistance acquisition (for example, TR\n            <jats:sub>34</jats:sub>\n            /L98H) have been reported. These mutations can also be found in isolates recovered from patients. Environmental azole resistance acquisition has been reported on several continents. Here we describe, for the first time, the occurrence of azole-resistant\n            <jats:named-content content-type=\"genus-species\">A. fumigatus</jats:named-content>\n            isolates of environmental origin in Switzerland with\n            <jats:italic>cyp51A</jats:italic>\n            mutations, and we show that these isolates can also be recovered from a few patients. While the TR\n            <jats:sub>34</jats:sub>\n            /L98H mutation was dominant, a single azole-resistant isolate exhibited a\n            <jats:italic>cyp51A</jats:italic>\n            mutation (G54R) that was reported only for clinical isolates. In conclusion, our study demonstrates that azole resistance with an environmental signature is present in environments and patients of Swiss origin and that mutations believed to be unique to clinical settings are now also observed in the environment.\n          </jats:p>","is_dataset_classified":null,"base_score":4.110873864173311,"endowment":4.110873864173311,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29437612","pmcid":"PMC5913999","openalex_id":"https://openalex.org/W2793149778","authors":[],"funders":[{"funder_name":"Swiss National Research Foundation","grant_id":"31003A_172958","title":null}],"total_grants":1,"fwci":5.0509,"citation_percentile":0.96525344,"influential_citations":0,"citation_trend":[{"year":2018,"count":3},{"year":2019,"count":10},{"year":2020,"count":6},{"year":2021,"count":18},{"year":2022,"count":9},{"year":2023,"count":7},{"year":2024,"count":2},{"year":2025,"count":5}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://aac.asm.org/content/aac/62/4/e02088-17.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/62/4/e02088-17.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.02088-17","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.02088-17","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29437612","host_type":"repository"},{"url":"https://serval.unil.ch/notice/serval:BIB_702EAF31F853","host_type":"repository"},{"url":"https://archive-ouverte.unige.ch/unige:111256","host_type":"repository"},{"url":"https://iris.unil.ch/handle/iris/219145","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5913999","host_type":"repository"},{"url":"https://iris.unil.ch/bitstreams/0f79c1ee-a888-4bbe-8ea9-89e8728a7d1a/download","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5913999","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5913999?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Antifungal resistance and susceptibility","Fungal Infections and Studies","Infectious Diseases and Mycology","Antifungal Agents","Aspergillus fumigatus","Azoles","Cytochrome P-450 Enzyme System","Drug Resistance, Fungal","Fungal Proteins","Microbial Sensitivity Tests","Switzerland"],"mesh_terms":["Antifungal Agents","Aspergillus fumigatus","Azoles","Cytochrome P-450 Enzyme System","Fungal Proteins","Microbial Sensitivity Tests","Switzerland","Drug Resistance, Fungal"],"keywords":["Aspergillus fumigatus","Azole","Microbiology","Biology","Fungus","Mutation","Aspergillus","Drug resistance","Gene","Antifungal","Genetics","Botany","Antifungal agents","Antifungal Resistance"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T03:29:13.321064Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}