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Ongoing clinical trials will provide additional data on the virologic activity of dolutegravir across subject viruses with and without prevalent polymorphic substitutions.</jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2013,"id":604955,"datarank":1.6460683002917622,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":1.1967084592586634,"self_endowment_contribution":0.4493598410330987,"citer_contribution":1.1967084592586634,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":16,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1552289,"name":"Samiul Hasan","orcid":null,"position":1,"is_corresponding":false},{"id":1552290,"name":"Heather Madsen","orcid":null,"position":2,"is_corresponding":false},{"id":692964,"name":"Joseph Horton","orcid":null,"position":3,"is_corresponding":false},{"id":1552291,"name":"Felix DeAnda","orcid":null,"position":4,"is_corresponding":false},{"id":1552292,"name":"Louise Martin-Carpenter","orcid":null,"position":5,"is_corresponding":false},{"id":1552293,"name":"Akihiko Sato","orcid":null,"position":6,"is_corresponding":false},{"id":1552294,"name":"Robert Cuffe","orcid":null,"position":7,"is_corresponding":false},{"id":1107954,"name":"Shuguang Chen","orcid":null,"position":8,"is_corresponding":false},{"id":654602,"name":"Mark Underwood","orcid":null,"position":9,"is_corresponding":false},{"id":1376229,"name":"Garrett Nichols","orcid":null,"position":10,"is_corresponding":false},{"id":692070,"name":"Cindy Vavro","orcid":"0000-0001-7179-3405","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Prevalent Polymorphisms in Wild-Type HIV-1 Integrase Are Unlikely To Engender Drug Resistance to Dolutegravir (S/GSK1349572)","abstract":"<jats:title>ABSTRACT</jats:title><jats:p>The majority of HIV-1 integrase amino acid sites are highly conserved, suggesting that most are necessary to carry out the critical structural and functional roles of integrase. We analyzed the 34 most variable sites in integrase (&gt;10% variability) and showed that prevalent polymorphic amino acids at these positions did not affect susceptibility to the integrase inhibitor dolutegravir (S/GSK1349572), as demonstrated both<jats:italic>in vitro</jats:italic>(in site-directed mutagenesis studies) and<jats:italic>in vivo</jats:italic>(in a phase IIa study of dolutegravir monotherapy in HIV-infected individuals). Ongoing clinical trials will provide additional data on the virologic activity of dolutegravir across subject viruses with and without prevalent polymorphic substitutions.</jats:p>","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23295935","pmcid":"PMC3591886","openalex_id":"https://openalex.org/W2115438976","authors":[],"funders":[],"total_grants":0,"fwci":2.4254,"citation_percentile":0.88951163,"influential_citations":0,"citation_trend":[{"year":2013,"count":4},{"year":2014,"count":5},{"year":2015,"count":5},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2021,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://aac.asm.org/content/aac/57/3/1379.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/57/3/1379.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.01791-12","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.01791-12","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23295935","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3591886","host_type":"repository"}],"fields_of_study":["HIV/AIDS drug development and treatment","Biochemical and Molecular Research","HIV Research and Treatment","Amino Acid Sequence","Conserved Sequence","HIV Infections","HIV Integrase","HIV Integrase Inhibitors","HIV-1","Heterocyclic Compounds, 3-Ring","Humans","Molecular Sequence Data","Mutagenesis, Site-Directed","Oxazines","Piperazines","Polymorphism, Genetic","Pyridones","Randomized Controlled Trials as Topic","Dolutegravir"],"mesh_terms":["Dolutegravir","Amino Acid Sequence","Heterocyclic Compounds, 3-Ring","Humans","Molecular Sequence Data","Oxazines","Piperazines","Polymorphism, Genetic","Pyridones","HIV-1","HIV Infections","Randomized Controlled Trials as Topic","Mutagenesis, Site-Directed","Conserved Sequence","HIV Integrase","HIV Integrase Inhibitors"],"keywords":["Dolutegravir","Integrase","Integrase inhibitor","Virology","Biology","Genetics","Mutagenesis","Mutation","Human immunodeficiency virus (HIV)","Gene","Viral load","Antiretroviral therapy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T01:16:20.077406Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}