{"doi":"10.1128/aac.01536-06","title":"Serum Differentially Alters the Antifungal Properties of Echinocandin Drugs","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse\n            <jats:italic>Candida</jats:italic>\n            spp. and\n            <jats:italic>Aspergillus</jats:italic>\n            spp. Consistent with a direct drug interaction, serum decreased the sensitivity of glucan synthase to echinocandin drugs.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2007,"id":590950,"datarank":6.477006913451631,"base_score":4.709530201312334,"endowment":4.709530201312334,"self_citation_contribution":0.7064295301968502,"citation_network_contribution":5.770577383254781,"self_endowment_contribution":0.7064295301968502,"citer_contribution":5.770577383254781,"corpus_percentile":null,"corpus_rank":null,"citation_count":110,"citer_count":91,"citers_with_citation_signal":87,"citers_with_endowment":87,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1511947,"name":"Guillermo Garcia-Effron","orcid":null,"position":1,"is_corresponding":false},{"id":1118601,"name":"Sergey Balashov","orcid":null,"position":2,"is_corresponding":false},{"id":1511948,"name":"Guillaume Delmas","orcid":null,"position":3,"is_corresponding":false},{"id":336884,"name":"Steven Park","orcid":"0000-0002-6757-1559","position":4,"is_corresponding":false},{"id":336885,"name":"David S. Perlin","orcid":"0000-0002-1268-5524","position":5,"is_corresponding":false},{"id":506525,"name":"Padmaja Paderu","orcid":"0000-0003-2996-6362","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Serum Differentially Alters the Antifungal Properties of Echinocandin Drugs","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse\n            <jats:italic>Candida</jats:italic>\n            spp. and\n            <jats:italic>Aspergillus</jats:italic>\n            spp. Consistent with a direct drug interaction, serum decreased the sensitivity of glucan synthase to echinocandin drugs.\n          </jats:p>","is_dataset_classified":null,"base_score":4.709530201312334,"endowment":4.709530201312334,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17420211","pmcid":"PMC1891414","openalex_id":"https://openalex.org/W2122363207","authors":[],"funders":[],"total_grants":0,"fwci":8.5506,"citation_percentile":0.98410954,"influential_citations":0,"citation_trend":[{"year":2012,"count":12},{"year":2013,"count":12},{"year":2014,"count":2},{"year":2015,"count":6},{"year":2017,"count":4},{"year":2018,"count":3},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":2}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.01536-06","host_type":"journal"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.01536-06","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.01536-06","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17420211","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1891414","host_type":"repository"},{"url":"https://doi.org/10.7270/q2028vb5","host_type":"repository"}],"fields_of_study":["Antifungal resistance and susceptibility","Fungal Biology and Applications","Fungal Infections and Studies","Anidulafungin","Animals","Antifungal Agents","Aspergillus fumigatus","Candida albicans","Caspofungin","Drug Interactions","Drug Resistance, Fungal","Echinocandins","Glucosyltransferases","Humans","Lipopeptides","Lipoproteins","Micafungin","Mice","Mice, Inbred BALB C","Microbial Sensitivity Tests","Peptides, Cyclic","Serum"],"mesh_terms":["Caspofungin","Micafungin","Anidulafungin","Animals","Antifungal Agents","Aspergillus fumigatus","Candida albicans","Drug Interactions","Glucosyltransferases","Humans","Lipoproteins","Mice, Inbred BALB C","Microbial Sensitivity Tests","Peptides, Cyclic","Drug Resistance, Fungal","Serum","Mice","Echinocandins","Lipopeptides"],"keywords":["Echinocandin","Anidulafungin","Micafungin","Caspofungin","Echinocandins","Pharmacology","Antifungal","Antifungal drug","Microbiology","Drug","Biology","Medicine","Fluconazole"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T13:19:30.975117Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}