{"doi":"10.1128/aac.01514-21","title":"A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus","abstract":". Focusing on M. abscessus, which causes the most difficult to cure NTM disease, we show that EC/11716 is bactericidal, active against drug-tolerant biofilms, and efficacious in a murine model of M. abscessus lung infection. Based on resistant mutant selection experiments, we report a low frequency of resistance to EC/11716 and confirm DNA gyrase as its target. Our findings demonstrate the potential of NBTIs as anti-M. abscessus and possibly broad-spectrum anti-mycobacterial agents.","journal":"Antimicrobial Agents and Chemotherapy","year":2021,"id":174835,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9559,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":684109,"name":"Rubén González del Río","orcid":null,"position":1,"is_corresponding":false},{"id":684110,"name":"Mónica Cacho-Izquierdo","orcid":null,"position":2,"is_corresponding":false},{"id":684111,"name":"Fátima Ortega","orcid":null,"position":3,"is_corresponding":false},{"id":540684,"name":"Joël Lelièvre","orcid":"0000-0001-6574-4957","position":4,"is_corresponding":false},{"id":655314,"name":"David Barros-Aguirre","orcid":"0000-0002-4099-0438","position":5,"is_corresponding":false},{"id":699727,"name":"Wassihun Wedajo Aragaw","orcid":"0000-0002-4199-2224","position":6,"is_corresponding":false},{"id":714968,"name":"Matthew D. Zimmerman","orcid":null,"position":7,"is_corresponding":false},{"id":641334,"name":"Marissa Lindman","orcid":null,"position":8,"is_corresponding":false},{"id":283116,"name":"Véronique Dartois","orcid":"0000-0001-9470-5009","position":9,"is_corresponding":false},{"id":270338,"name":"Martin Gengenbacher","orcid":"0000-0002-0208-5920","position":10,"is_corresponding":false},{"id":270341,"name":"Thomas Dick","orcid":"0000-0002-9604-9452","position":11,"is_corresponding":false},{"id":319076,"name":"Uday S. Ganapathy","orcid":null,"position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T23:47:06.584146Z","pmid":"34606340","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}