{"doi":"10.1128/aac.01346-23","title":"<i>In vitro</i> activity of meropenem-vaborbactam plus aztreonam against metallo-β-lactamase-producing <i>Klebsiella pneumoniae</i>","abstract":"ABSTRACT We evaluated the in vitro activity of meropenem-vaborbactam plus aztreonam (MEV-ATM) against 140 metallo-β-lactamase (MBL)-producing Klebsiella pneumoniae isolates. Among them, 25 isolates (17.9%) displayed minimum inhibitory concentrations (MIC) ≥ 8 µg/mL, while 112 (80.0%) had MIC ≤ 2 µg/mL. Genomic analysis and subsequent gene cloning experiments revealed OmpK36 134-135GD-insertion and increased carbapenemase gene ( bla NDM-1 and bla OXA-48-like ) copy numbers are the main factors responsible for MEV-ATM non-susceptibility. Notably, MEV-ATM is actively against aztreonam-avibactam-resistant mutants due to CMY-16 mutations.","journal":"Antimicrobial Agents and Chemotherapy","year":2024,"id":457281,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":729401,"name":"Elena Shashkina","orcid":null,"position":1,"is_corresponding":false},{"id":877188,"name":"Tingyu Chu","orcid":"0009-0001-0578-3142","position":2,"is_corresponding":false},{"id":1282596,"name":"Zhichen Zhu","orcid":"0000-0002-3144-4611","position":3,"is_corresponding":false},{"id":373652,"name":"Bingjie Wang","orcid":"0000-0002-9952-1580","position":4,"is_corresponding":false},{"id":231558,"name":"Barry N. Kreiswirth","orcid":"0000-0002-0243-131X","position":5,"is_corresponding":false},{"id":231557,"name":"Liang Chen","orcid":"0000-0001-5845-2235","position":6,"is_corresponding":false},{"id":881861,"name":"Astrid V. Cienfuegos-Gallet","orcid":"0000-0002-3407-6463","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T02:03:37.136946Z","pmid":"38426743","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}