{"doi":"10.1128/aac.01308-07","title":"Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>Searching the database for mouse homologs of the antimicrobial peptide human beta-defensin-3 (hBD-3) revealed highest identity (69%) to mouse beta-defensin-14 (mBD-14). Recombinant mBD-14 exhibited broad-spectrum, nanomolar microbicidal activity. Treatment of keratinocytes with gamma interferon or transforming growth factor alpha increased mBD-14 gene expression. These data suggest that mBD-14 is the functional ortholog of hBD-3.</jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2008,"id":671853,"datarank":0.6010999777848708,"base_score":4.007333185232471,"endowment":4.007333185232471,"self_citation_contribution":0.6010999777848708,"citation_network_contribution":0.0,"self_endowment_contribution":0.6010999777848708,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1755262,"name":"Rainer Podschun","orcid":null,"position":1,"is_corresponding":false},{"id":1755263,"name":"Sabine Schubert","orcid":null,"position":2,"is_corresponding":false},{"id":1755264,"name":"Jens M. Schröder","orcid":null,"position":3,"is_corresponding":false},{"id":1755265,"name":"Jürgen Harder","orcid":null,"position":4,"is_corresponding":false},{"id":1755266,"name":"Ehrhardt Proksch","orcid":null,"position":5,"is_corresponding":false},{"id":1755261,"name":"Kerstin Hinrichsen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>Searching the database for mouse homologs of the antimicrobial peptide human beta-defensin-3 (hBD-3) revealed highest identity (69%) to mouse beta-defensin-14 (mBD-14). Recombinant mBD-14 exhibited broad-spectrum, nanomolar microbicidal activity. Treatment of keratinocytes with gamma interferon or transforming growth factor alpha increased mBD-14 gene expression. These data suggest that mBD-14 is the functional ortholog of hBD-3.</jats:p>","is_dataset_classified":null,"base_score":4.007333185232471,"endowment":4.007333185232471,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18332171","pmcid":"PMC2346663","openalex_id":"https://openalex.org/W2128115224","authors":[],"funders":[],"total_grants":0,"fwci":3.6631,"citation_percentile":0.92718023,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":3},{"year":2014,"count":1},{"year":2015,"count":4},{"year":2016,"count":3},{"year":2017,"count":6},{"year":2018,"count":2},{"year":2019,"count":3},{"year":2021,"count":2},{"year":2022,"count":5},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2346663","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2346663","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.01308-07","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.01308-07","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18332171","host_type":"repository"}],"fields_of_study":["Antimicrobial Peptides and Activities","Immune Response and Inflammation","Amino Acid Sequence","Animals","Anti-Infective Agents","Candida albicans","Cells, Cultured","Gene Expression","Humans","Interferon-gamma","Keratinocytes","Mice","Microbial Sensitivity Tests","Molecular Sequence Data","RNA, Messenger","Reverse Transcriptase Polymerase Chain Reaction","Sequence Homology, Amino Acid","Staphylococcus aureus","Transforming Growth Factor alpha","beta-Defensins"],"mesh_terms":["Amino Acid Sequence","Animals","Anti-Infective Agents","Candida albicans","Cells, Cultured","Humans","Interferon-gamma","Microbial Sensitivity Tests","Molecular Sequence Data","RNA, Messenger","Staphylococcus aureus","Keratinocytes","Gene Expression","Transforming Growth Factor alpha","Sequence Homology, Amino Acid","Reverse Transcriptase Polymerase Chain Reaction","beta-Defensins","Mice"],"keywords":["Defensin","Beta defensin","Biology","BETA (programming language)","Gene","Antimicrobial","Antimicrobial peptides","Recombinant DNA","Peptide","Molecular biology","Microbiology","Genetics","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T04:59:59.960137Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}