{"doi":"10.1128/aac.01301-24","title":"Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated <i>Candida auris</i> infection","abstract":"ABSTRACT Only three classes of antifungal drugs are currently in clinical use. Here, we report that derivatives of the malarial drug mefloquine have broad-spectrum antifungal activity including difficult-to-treat molds and endemic fungi. Pharmacokinetic and efficacy studies of NSC-4377 indicate that it penetrates the central nervous system and is active against Candida auris in vivo . These data strongly support the further development of mefloquine analogs as a potentially new class of antifungal molecules.","journal":"Antimicrobial Agents and Chemotherapy","year":2024,"id":474211,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1310414,"name":"Marhiah C. Montoya","orcid":"0000-0002-6112-5531","position":1,"is_corresponding":false},{"id":980018,"name":"Xiaoyu Wang","orcid":"0000-0002-0861-0204","position":2,"is_corresponding":false},{"id":320557,"name":"Robert Żarnowski","orcid":"0000-0001-6343-1500","position":3,"is_corresponding":false},{"id":251454,"name":"David R. Andes","orcid":"0000-0002-7927-9950","position":4,"is_corresponding":false},{"id":883130,"name":"Marvin J. Meyers","orcid":"0000-0001-5484-619X","position":5,"is_corresponding":false},{"id":7763,"name":"Noelle S. Williams","orcid":"0000-0003-1894-5742","position":6,"is_corresponding":false},{"id":344687,"name":"Damian J. Krysan","orcid":"0000-0001-6330-3365","position":7,"is_corresponding":false},{"id":1107771,"name":"Soumitra Guin","orcid":"0000-0002-8562-225X","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-19T02:06:09.108857Z","pmid":"39365066","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}