{"doi":"10.1128/aac.01188-20","title":"<i>In Vitro</i> and <i>In Vivo</i> Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of <i>Leishmania amazonensis</i>","abstract":"Phenotypic assay against Leishmania amazonensis in vitro and in vivo led to identification of an adamantyl-based phenyl sulfonyl acetamide (compound 1) as a promising antileishmanial agent. Compound 1 inhibited the growth of intracellular forms of L. amazonensis (50% inhibitory concentration [IC 50 ] = 4 μM) and exhibited low toxicity to host cells, with a selectivity index (SI) of &gt;125. However, in a cutaneous leishmaniasis (CL) mouse model, compound 1 did not reduce lesions and parasite load when administered as monotherapy or when given simultaneously with a suboptimal dose of miltefosine.","journal":"Antimicrobial Agents and Chemotherapy","year":2020,"id":108202,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":505307,"name":"Huaisheng Zhang","orcid":"0000-0002-5579-4608","position":1,"is_corresponding":false},{"id":518941,"name":"Marcos Meuser Batista","orcid":"0000-0003-4783-7011","position":2,"is_corresponding":false},{"id":518942,"name":"Gabriel Melo de Oliveira","orcid":"0000-0002-6766-3613","position":3,"is_corresponding":false},{"id":518943,"name":"Kelly Cristina Demarque","orcid":"0000-0001-5170-5068","position":4,"is_corresponding":false},{"id":519831,"name":"Natália Lins Silva-Gomes","orcid":null,"position":5,"is_corresponding":false},{"id":518944,"name":"Otacílio C. Moreira","orcid":"0000-0002-5340-8697","position":6,"is_corresponding":false},{"id":505309,"name":"Ifedayo Victor Ogungbe","orcid":"0000-0002-8048-5137","position":7,"is_corresponding":false},{"id":518945,"name":"Maria de Nazaré Correia Soeiro","orcid":"0000-0003-0078-6106","position":8,"is_corresponding":false},{"id":518940,"name":"Camila C. Santos","orcid":"0000-0003-0207-0902","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-18T23:12:43.081337Z","pmid":"32928731","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}