{"doi":"10.1128/aac.01183-25","title":"Sterilizing activity of spectinamide MBX-4888A when replacing linezolid in the Nix-TB regimen in the relapsing BALB/c mouse model of tuberculosis","abstract":"Spectinamides have garnered interest as experimental tuberculosis therapeutics owing to their safety profile and efficacy as partner agents when used in conjunction with established regimens in mice. The Nix-TB regimen of bedaquiline, pretomanid, and linezolid represents a short, effective regimen recommended for treatment of pre-extensively drug-resistant tuberculosis. However, linezolid administration is associated with severe adverse events that limit its use. Here we present preclinical data comparing Nix-TB regimens anchored by either linezolid or spectinamide MBX-4888A.","journal":"Antimicrobial Agents and Chemotherapy","year":2025,"id":576429,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":560538,"name":"Michaël Scherman","orcid":"0000-0002-3125-8640","position":1,"is_corresponding":false},{"id":458979,"name":"Firat Kaya","orcid":"0000-0001-8655-2065","position":2,"is_corresponding":false},{"id":942203,"name":"Samanthi L. Waidyarachchi","orcid":"0009-0004-0090-7291","position":3,"is_corresponding":false},{"id":540686,"name":"Jiuyu Liu","orcid":"0000-0002-0102-6590","position":4,"is_corresponding":false},{"id":1478173,"name":"Joel N. Rushefsky","orcid":null,"position":5,"is_corresponding":false},{"id":574871,"name":"Michelle M. Butler","orcid":"0000-0001-6894-8621","position":6,"is_corresponding":false},{"id":391953,"name":"Terry L. Bowlin","orcid":"0000-0002-9184-5791","position":7,"is_corresponding":false},{"id":696626,"name":"Bernd Meibohm","orcid":"0000-0003-3923-3648","position":8,"is_corresponding":false},{"id":341223,"name":"Mercedes Gonzalez‐Juarrero","orcid":"0000-0002-4045-2365","position":9,"is_corresponding":false},{"id":458144,"name":"Anne J. Lenaerts","orcid":null,"position":10,"is_corresponding":false},{"id":317196,"name":"Matthew Zimmerman","orcid":"0000-0002-4390-3555","position":11,"is_corresponding":false},{"id":360604,"name":"Richard Lee","orcid":"0000-0002-2397-0443","position":12,"is_corresponding":false},{"id":477426,"name":"Gregory T. Robertson","orcid":"0000-0001-7157-4034","position":13,"is_corresponding":false},{"id":1477877,"name":"Nathan Peroutka‐Bigus","orcid":"0000-0001-5212-9541","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T02:57:56.636458Z","pmid":"41025648","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}