{"doi":"10.1128/aac.01122-08","title":"Postantibiotic Effect of Tigecycline against 14 Gram-Positive Organisms","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The in vitro postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects of tigecycline were determined for 14 gram-positive and gram-negative organisms. The pneumococcal, staphylococcal, and enterococcal PAEs were 1.9 to 5.1, 2.9 to 5.7, and 3.9 to 6.1 h, respectively, and those for\n            <jats:italic>Haemophilus influenzae</jats:italic>\n            ,\n            <jats:italic>Escherichia coli</jats:italic>\n            ,\n            <jats:italic>Klebsiella pneumoniae</jats:italic>\n            ,\n            <jats:italic>Enterobacter cloacae</jats:italic>\n            , and\n            <jats:italic>Acinetobacter baumannii</jats:italic>\n            were 1.1 to 5.0, 1.9 to 2.1, 1.7 to 1.8, 1.0 to 1.7, and 0.7 to 3 h, respectively. The PA-SMEs (four times the MIC) ranged from 6.7 to &gt;11 h for gram-positive organisms and from 2.3 to &gt;11.3 h for gram-negative organisms.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2009,"id":688677,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1799175,"name":"P. C. Appelbaum","orcid":null,"position":1,"is_corresponding":false},{"id":1799174,"name":"G. A. Pankuch","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Postantibiotic Effect of Tigecycline against 14 Gram-Positive Organisms","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The in vitro postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects of tigecycline were determined for 14 gram-positive and gram-negative organisms. The pneumococcal, staphylococcal, and enterococcal PAEs were 1.9 to 5.1, 2.9 to 5.7, and 3.9 to 6.1 h, respectively, and those for\n            <jats:italic>Haemophilus influenzae</jats:italic>\n            ,\n            <jats:italic>Escherichia coli</jats:italic>\n            ,\n            <jats:italic>Klebsiella pneumoniae</jats:italic>\n            ,\n            <jats:italic>Enterobacter cloacae</jats:italic>\n            , and\n            <jats:italic>Acinetobacter baumannii</jats:italic>\n            were 1.1 to 5.0, 1.9 to 2.1, 1.7 to 1.8, 1.0 to 1.7, and 0.7 to 3 h, respectively. The PA-SMEs (four times the MIC) ranged from 6.7 to &gt;11 h for gram-positive organisms and from 2.3 to &gt;11.3 h for gram-negative organisms.\n          </jats:p>","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19064899","pmcid":"PMC2630611","openalex_id":"https://openalex.org/W2102439564","authors":[],"funders":[],"total_grants":0,"fwci":0.1175,"citation_percentile":0.47386935,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2022,"count":1},{"year":2025,"count":1}],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2630611","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2630611","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.01122-08","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.01122-08","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19064899","host_type":"repository"}],"fields_of_study":["Antibiotic Resistance in Bacteria","Antibiotics Pharmacokinetics and Efficacy","Polyomavirus and related diseases","Anti-Bacterial Agents","Colony Count, Microbial","Gram-Negative Bacteria","Gram-Positive Bacteria","Microbial Sensitivity Tests","Minocycline","Tigecycline"],"mesh_terms":["Tigecycline","Anti-Bacterial Agents","Gram-Negative Bacteria","Gram-Positive Bacteria","Microbial Sensitivity Tests","Minocycline","Colony Count, Microbial"],"keywords":["Enterobacter cloacae","Tigecycline","Microbiology","Acinetobacter baumannii","Klebsiella pneumoniae","Gram","Acinetobacter","Biology","Klebsiella","Klebsiella oxytoca","Enterobacteriaceae","Haemophilus influenzae","Gram-negative bacteria","Staphylococcus aureus","Escherichia coli","Enterobacter","Streptococcus pneumoniae","Antibiotics","Bacteria","Pseudomonas aeruginosa"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T18:24:26.697104Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}