{"doi":"10.1128/aac.01106-16","title":"<i>In Vitro</i>\n            Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The\n            <jats:italic>in vitro</jats:italic>\n            activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical\n            <jats:named-content content-type=\"genus-species\">Candida</jats:named-content>\n            isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates)\n            <jats:named-content content-type=\"genus-species\">Candida</jats:named-content>\n            isolates.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2017,"id":608127,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1561711,"name":"Saeed Emami","orcid":null,"position":1,"is_corresponding":false},{"id":61407,"name":"Afsane Vaezi","orcid":"0000-0001-8261-7386","position":2,"is_corresponding":false},{"id":1561715,"name":"Seyedeh Mahdieh Hashemi","orcid":null,"position":3,"is_corresponding":false},{"id":1561717,"name":"Leila Faeli","orcid":null,"position":4,"is_corresponding":false},{"id":1561719,"name":"Kambiz Diba","orcid":null,"position":5,"is_corresponding":false},{"id":855006,"name":"Éric Dannaoui","orcid":"0000-0002-2817-3830","position":6,"is_corresponding":false},{"id":61050,"name":"Hamid Badali","orcid":"0000-0002-6010-8414","position":7,"is_corresponding":false},{"id":61132,"name":"Hamed Fakhim","orcid":"0000-0002-0517-7994","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"<i>In Vitro</i>\n            Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The\n            <jats:italic>in vitro</jats:italic>\n            activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical\n            <jats:named-content content-type=\"genus-species\">Candida</jats:named-content>\n            isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates)\n            <jats:named-content content-type=\"genus-species\">Candida</jats:named-content>\n            isolates.\n          </jats:p>","is_dataset_classified":null,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27795371","pmcid":"PMC5192144","openalex_id":"https://openalex.org/W2537198628","authors":[],"funders":[{"funder_name":"Mazandaran University of Medical Sciences","grant_id":"2321","title":null}],"total_grants":1,"fwci":3.8606,"citation_percentile":0.93682644,"influential_citations":0,"citation_trend":[{"year":2017,"count":4},{"year":2018,"count":7},{"year":2019,"count":7},{"year":2020,"count":4},{"year":2021,"count":2},{"year":2022,"count":3},{"year":2023,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://aac.asm.org/content/aac/61/1/e01106-16.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/61/1/e01106-16.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.01106-16","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.01106-16","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27795371","host_type":"repository"},{"url":"https://hal.u-pec.fr/hal-03997772","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5192144","host_type":"repository"}],"fields_of_study":["Antifungal resistance and susceptibility","Fungal Infections and Studies","Infectious Diseases and Mycology","Antifungal Agents","Azoles","Candida","Drug Resistance, Fungal","Fluconazole","Microbial Sensitivity Tests","Triazoles"],"mesh_terms":["Antifungal Agents","Azoles","Candida","Microbial Sensitivity Tests","Triazoles","Fluconazole","Drug Resistance, Fungal"],"keywords":["Fluconazole","Azole","Microbiology","Biology","In vitro","Antifungal","Fungi imperfecti","Biochemistry","Candida Species","In Vitro Susceptibility","Triazole Derivatives"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:32:41.834589Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}