{"doi":"10.1128/aac.01027-21","title":"Mutations in the HIV-1 3′-Polypurine Tract Can Confer Dolutegravir Resistance","abstract":"With interest we read the Letter to the Editor of Wei and Sluis-Cremer about the role of human immunodeficiency virus type 1 (HIV-1) 3′-polypurine tract (3′PPT) mutations in dolutegravir (DTG) resistance (1). In particular, they report that the 3′PPT mutations identified by Wijting et al. (2) in a patient that failed on DTG monotherapy do not confer DTG resistance in a phenotypic drug resistance assay and conclude that genotypic analysis of the 3′PPT in HIV-1 resistance to integrase strand transfer inhibitors (INSTIs) is not warranted. However, we argue that it is too early for such a conclusion.","journal":"Antimicrobial Agents and Chemotherapy","year":2021,"id":188021,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":489358,"name":"Bep Klaver","orcid":null,"position":1,"is_corresponding":false},{"id":277331,"name":"Ben Berkhout","orcid":"0000-0002-1905-8486","position":2,"is_corresponding":false},{"id":277329,"name":"Atze T. Das","orcid":"0000-0001-7891-2315","position":3,"is_corresponding":false},{"id":748320,"name":"José G. Dekker","orcid":"0009-0008-4994-9600","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-18T23:49:05.976005Z","pmid":"34633840","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}