{"doi":"10.1128/aac.01009-23","title":"The emergence of cefiderocol resistance in <i>Pseudomonas aeruginosa</i> from a heteroresistant isolate during prolonged therapy","abstract":"ABSTRACT Cefiderocol is a siderophore cephalosporin designed to target multi-drug-resistant Gram-negative bacteria. Previously, the emergence of cefiderocol non-susceptibility has been associated with mutations in the chromosomal cephalosporinase (PDC) along with mutations in the PirA and PiuA/D TonB-dependent receptor pathways. Here, we report a clinical case of cefiderocol-resistant P. aeruginosa that emerged in a patient during treatment. This resistance was associated with mutations not previously reported, suggesting potential novel pathways to cefiderocol resistance.","journal":"Antimicrobial Agents and Chemotherapy","year":2023,"id":325612,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1043867,"name":"Stephanie L Egge","orcid":"0000-0001-8232-0443","position":1,"is_corresponding":false},{"id":462931,"name":"Kady Phe","orcid":"0000-0001-7118-0510","position":2,"is_corresponding":false},{"id":356928,"name":"Rodrigo P. Baptista","orcid":"0000-0002-1806-8260","position":3,"is_corresponding":false},{"id":439780,"name":"Vincent H. Tam","orcid":"0000-0001-7071-5376","position":4,"is_corresponding":false},{"id":582538,"name":"William R. Miller","orcid":"0000-0002-1518-2973","position":5,"is_corresponding":false},{"id":1043866,"name":"Nicholas S Teran","orcid":"0000-0001-7063-2191","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T01:08:28.266998Z","pmid":"38063509","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}