{"doi":"10.1128/aac.00998-16","title":"<i>In Vitro</i>\n            Activity of 3-Triazeneindoles against Mycobacterium tuberculosis and Mycobacterium avium","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Among 230 target-synthesized indole-based compounds, seven 3-triazenoindoles showed MICs of 0.2 to 0.5 μg/ml against\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Mycobacterium tuberculosis</jats:named-content>\n            strain H37Rv and isoniazid-resistant human isolate CN-40. The TU112 compound was active also against a dormant form of\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">M. tuberculosis</jats:named-content>\n            . Some of these triazenoindoles were active against\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Mycobacterium avium</jats:named-content>\n            , with MICs of 0.05 to 0.5 μg/ml. The selectivity indices (SI) for\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">M. tuberculosis</jats:named-content>\n            and\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">M. avium</jats:named-content>\n            were significantly higher than 10, making these compounds acceptable for the next testing step.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2016,"id":593233,"datarank":0.979933158211368,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.5840745587690791,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.5840745587690791,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":7,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1518347,"name":"Albert Kornienko","orcid":null,"position":1,"is_corresponding":false},{"id":1518348,"name":"Konstantin Majorov","orcid":null,"position":2,"is_corresponding":false},{"id":17832,"name":"Pavel Ivanov","orcid":"0000-0002-7986-7760","position":3,"is_corresponding":false},{"id":1518349,"name":"Tatiana Kondratieva","orcid":null,"position":4,"is_corresponding":false},{"id":1518350,"name":"Maria Korotetskaya","orcid":null,"position":5,"is_corresponding":false},{"id":1518351,"name":"Alexander S. Apt","orcid":null,"position":6,"is_corresponding":false},{"id":1518353,"name":"Elena Salina","orcid":null,"position":7,"is_corresponding":false},{"id":1518354,"name":"Valeriya Velezheva","orcid":null,"position":8,"is_corresponding":false},{"id":1518346,"name":"Boris V. Nikonenko","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"<i>In Vitro</i>\n            Activity of 3-Triazeneindoles against Mycobacterium tuberculosis and Mycobacterium avium","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Among 230 target-synthesized indole-based compounds, seven 3-triazenoindoles showed MICs of 0.2 to 0.5 μg/ml against\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Mycobacterium tuberculosis</jats:named-content>\n            strain H37Rv and isoniazid-resistant human isolate CN-40. The TU112 compound was active also against a dormant form of\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">M. tuberculosis</jats:named-content>\n            . Some of these triazenoindoles were active against\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Mycobacterium avium</jats:named-content>\n            , with MICs of 0.05 to 0.5 μg/ml. The selectivity indices (SI) for\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">M. tuberculosis</jats:named-content>\n            and\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">M. avium</jats:named-content>\n            were significantly higher than 10, making these compounds acceptable for the next testing step.\n          </jats:p>","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27503657","pmcid":"PMC5038256","openalex_id":"https://openalex.org/W2522808041","authors":[],"funders":[{"funder_name":"Russian Foundation for Basic Research","grant_id":"14-04-01688","title":null},{"funder_name":"Russian Science Foundation","grant_id":"15-15-30020","title":null}],"total_grants":2,"fwci":1.8997,"citation_percentile":0.86416919,"influential_citations":0,"citation_trend":[{"year":2017,"count":4},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":3},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://aac.asm.org/content/aac/60/10/6422.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/60/10/6422.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.00998-16","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.00998-16","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27503657","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5038256","host_type":"repository"}],"fields_of_study":["Synthesis and Catalytic Reactions","Synthesis and Biological Evaluation","Click Chemistry and Applications"],"mesh_terms":["Antitubercular Agents","Drug Evaluation, Preclinical","Humans","Indoles","Isoniazid","Microbial Sensitivity Tests","Mycobacterium avium","Mycobacterium tuberculosis","Drug Resistance, Bacterial"],"keywords":["Mycobacterium tuberculosis","Isoniazid","Microbiology","Mycobacterium","Tuberculosis","Strain (injury)","In vitro","Biology","Chemistry","Medicine","Biochemistry","Pathology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T17:54:50.627966Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}