{"doi":"10.1128/aac.00782-20","title":"HIV Coinfection Is Associated with Low-Fitness <i>rpoB</i> Variants in Rifampicin-Resistant Mycobacterium tuberculosis","abstract":"We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.","journal":"Antimicrobial Agents and Chemotherapy","year":2020,"id":82114,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":424025,"name":"Daniela Brites","orcid":"0000-0002-8090-2287","position":1,"is_corresponding":false},{"id":425230,"name":"Miriam Reinhard","orcid":null,"position":2,"is_corresponding":false},{"id":424026,"name":"Kathrin Zürcher","orcid":"0000-0002-7915-3194","position":3,"is_corresponding":false},{"id":424027,"name":"Sònia Borrell","orcid":"0000-0001-6661-6957","position":4,"is_corresponding":false},{"id":424028,"name":"Marie Ballif","orcid":"0000-0003-3133-3011","position":5,"is_corresponding":false},{"id":424029,"name":"Lukas Fenner","orcid":"0000-0003-3309-4835","position":6,"is_corresponding":false},{"id":424030,"name":"Helen Cox","orcid":"0000-0002-6538-7192","position":7,"is_corresponding":false},{"id":424031,"name":"Liliana K. Rutaihwa","orcid":"0000-0002-4092-2291","position":8,"is_corresponding":false},{"id":266683,"name":"Robert J. Wilkinson","orcid":"0000-0002-2753-1800","position":9,"is_corresponding":false},{"id":61432,"name":"Marcel Yotebieng","orcid":"0000-0003-2110-2631","position":10,"is_corresponding":false},{"id":425231,"name":"E Jane Carter","orcid":null,"position":11,"is_corresponding":false},{"id":425232,"name":"Alash’le Abimiku","orcid":null,"position":12,"is_corresponding":false},{"id":424032,"name":"Olivier Marcy","orcid":"0000-0003-3350-112X","position":13,"is_corresponding":false},{"id":287957,"name":"Eduardo Gotuzzo","orcid":"0000-0003-1747-4352","position":14,"is_corresponding":false},{"id":424033,"name":"Anchalee Avihingsanon","orcid":"0000-0003-3222-9611","position":15,"is_corresponding":false},{"id":387855,"name":"Nicola M. Zetola","orcid":"0000-0003-0712-8579","position":16,"is_corresponding":false},{"id":424034,"name":"Basra Doulla","orcid":"0000-0001-8197-1391","position":17,"is_corresponding":false},{"id":108181,"name":"Erik C. Böttger","orcid":"0000-0002-2570-0121","position":18,"is_corresponding":false},{"id":4469,"name":"Matthias Egger","orcid":"0000-0001-7462-5132","position":19,"is_corresponding":false},{"id":424035,"name":"Sébastien Gagneux","orcid":"0000-0001-7783-9048","position":20,"is_corresponding":false},{"id":424024,"name":"Chloé Loiseau","orcid":"0000-0003-4889-2784","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T21:53:19.932222Z","pmid":"32718966","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}