{"doi":"10.1128/aac.00771-21","title":"Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates","abstract":"for 218 of these isolates demonstrated many nonsynonymous single nucleotide polymorphisms; the most frequent mutations were G1128R (69% of isolates mixed or mutant), Q1081K/R (68%), G223S (25%), N1045K (16%), and D1116G/N/Y (16%). The G223S mutation was associated with decreased susceptibility to SJ733, PA92, and KAE609. The D1116G/N/Y mutations were associated with decreased susceptibility to SJ733, and the presence of mutations at both codons 223 and 1116 was associated with decreased susceptibility to PA92 and SJ733. In all of these cases, absolute differences in susceptibilities of wild-type (WT) and mutant parasites were modest. Analysis of clones separated from mixed field isolates consistently identified mutant clones as less susceptible than WT. Analysis of isolates from other sites demonstrated the presence of the G223S and D1116G/N/Y mutations across Uganda. Our results indicate that malaria parasites circulating in Uganda have a number of polymorphisms in PfATP4 and that modestly decreased susceptibility to PfATP4 inhibitors is associated with some mutations now present in Ugandan parasites.","journal":"Antimicrobial Agents and Chemotherapy","year":2021,"id":201474,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9216,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":647239,"name":"Stephanie A. Rasmussen","orcid":null,"position":1,"is_corresponding":false},{"id":780962,"name":"Aarti Ramanathan","orcid":null,"position":2,"is_corresponding":false},{"id":242450,"name":"Patrick K. Tumwebaze","orcid":"0000-0002-5933-1432","position":3,"is_corresponding":false},{"id":647235,"name":"Oswald Byaruhanga","orcid":null,"position":4,"is_corresponding":false},{"id":528692,"name":"Thomas Katairo","orcid":"0000-0002-2002-8911","position":5,"is_corresponding":false},{"id":242446,"name":"Victor Asua","orcid":"0000-0002-0489-4692","position":6,"is_corresponding":false},{"id":646374,"name":"Martin Okitwi","orcid":"0000-0003-2712-2174","position":7,"is_corresponding":false},{"id":647236,"name":"Stephen Orena","orcid":null,"position":8,"is_corresponding":false},{"id":244078,"name":"Jennifer Legac","orcid":null,"position":9,"is_corresponding":false},{"id":242447,"name":"Melissa D. Conrad","orcid":"0000-0002-9984-8030","position":10,"is_corresponding":false},{"id":242455,"name":"Samuel L. Nsobya","orcid":"0000-0003-4986-8823","position":11,"is_corresponding":false},{"id":242448,"name":"Özkan Aydemir","orcid":"0000-0002-3458-6527","position":12,"is_corresponding":false},{"id":242456,"name":"Jeffrey A. Bailey","orcid":"0000-0002-6899-8204","position":13,"is_corresponding":false},{"id":632935,"name":"Maëlle Duffey","orcid":"0000-0002-4319-0647","position":14,"is_corresponding":false},{"id":646375,"name":"Brett R. Bayles","orcid":"0000-0002-3474-4353","position":15,"is_corresponding":false},{"id":576261,"name":"Akhil B. Vaidya","orcid":"0000-0003-1063-5571","position":16,"is_corresponding":false},{"id":242451,"name":"Roland A. Cooper","orcid":"0000-0002-8437-9382","position":17,"is_corresponding":false},{"id":242457,"name":"Philip J. Rosenthal","orcid":"0000-0002-7953-7622","position":18,"is_corresponding":false},{"id":738607,"name":"Oriana Kreutzfeld","orcid":"0000-0003-2026-345X","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:50:56.394488Z","pmid":"34339273","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}