{"doi":"10.1128/aac.00718-18","title":"Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have\n            <i>In Vitro</i>\n            Activity against Cryptosporidium","abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Cryptosporidium</jats:named-content>\n            species cause significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition.\n          </jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2018,"id":662600,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":347266,"name":"David T. Bolick","orcid":"0000-0001-9281-085X","position":1,"is_corresponding":false},{"id":339939,"name":"Glynis L. Kolling","orcid":"0000-0001-8871-8129","position":2,"is_corresponding":false},{"id":1729816,"name":"Erin Stebbins","orcid":null,"position":3,"is_corresponding":false},{"id":246859,"name":"Christopher D. Huston","orcid":"0000-0002-5393-139X","position":4,"is_corresponding":false},{"id":23070,"name":"Richard L. Guerrant","orcid":null,"position":5,"is_corresponding":false},{"id":517600,"name":"Paul S. Hoffman","orcid":"0000-0001-5131-1077","position":6,"is_corresponding":false},{"id":105522,"name":"Luther A. Bartelt","orcid":"0000-0002-7596-4272","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have\n            <i>In Vitro</i>\n            Activity against Cryptosporidium","abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Cryptosporidium</jats:named-content>\n            species cause significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition.\n          </jats:p>","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30297368","pmcid":"PMC6256802","openalex_id":"https://openalex.org/W2894604419","authors":[],"funders":[{"funder_name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","grant_id":"K08AI108730","title":null},{"funder_name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","grant_id":"1R21 AI111604","title":null},{"funder_name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","grant_id":"1R21 AI30807","title":null},{"funder_name":"Bill and Melinda Gates Foundation","grant_id":"OPP1066140","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI101381","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"P20 GM125498","title":null},{"funder_name":"NIAAA NIH HHS","grant_id":"R21 AA030807","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI111604","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"P20 RR021905","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"P30 GM118228","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R21AA030807-01A1","title":"Role of glucocorticoid receptor-mediated mRNA decay in alcohol dependence"},{"funder_name":"National Institutes of Health","grant_id":"1R21AI111604-01","title":"PFOR inhibitor amixicile for treatment of drug resistant parasites and bacteria"},{"funder_name":"National Institutes of Health","grant_id":"5R21ES030807-02","title":"Human Exposure and Vulnerability to Manganese Contaminated Groundwater"},{"funder_name":"National Institutes of Health","grant_id":"5K08AI108730-02","title":"Cytokine signaling and IEC restitution in enteropathy: the Giardia paradigm"}],"total_grants":14,"fwci":1.176,"citation_percentile":0.73947039,"influential_citations":0,"citation_trend":[{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":3},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://aac.asm.org/content/aac/62/12/e00718-18.full.pdf","host_type":"journal"},{"url":"https://aac.asm.org/content/aac/62/12/e00718-18.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/AAC.00718-18","host_type":"publisher"},{"url":"https://doi.org/10.1128/aac.00718-18","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30297368","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6256802","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6256802","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6256802?pdf=render","host_type":"Europe_PMC"},{"url":"https://dx.doi.org/10.17615/kx06-sc65","host_type":""},{"url":"http://dx.doi.org/10.1128/AAC.00718-18","host_type":""},{"url":"https://dx.doi.org/10.1128/aac.00718-18","host_type":""}],"fields_of_study":["Parasitic Infections and Diagnostics","Pediatric health and respiratory diseases","Amoebic Infections and Treatments","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Antiprotozoal Agents","Benzamides","Cryptosporidiosis","Cryptosporidium parvum","Disease Models, Animal","Mice, Inbred C57BL","Nitro Compounds","Pyruvate Synthase","Thiazoles","Weight Loss"],"mesh_terms":["Animals","Antiprotozoal Agents","Benzamides","Cryptosporidiosis","Disease Models, Animal","Mice, Inbred C57BL","Nitro Compounds","Thiazoles","Weight Loss","Cryptosporidium parvum","Pyruvate Synthase"],"keywords":["Cryptosporidium","In vitro","Biology","Microbiology","Virology","Feces","Genetics","Malnutrition","Nitazoxanide","Environmental Enteropathy","Amixicile","Cryptosporidium parvum","Pyruvate Synthase","Antiprotozoal Agents","Cryptosporidiosis","Nitro Compounds","Mice, Inbred C57BL","Disease Models, Animal","Thiazoles","Benzamides","Weight Loss","Animals","Mechanisms of Action: Physiological Effects"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. Zero hunger"},{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T16:16:34.966193Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}