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Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.</jats:p>","journal":"Antimicrobial Agents and Chemotherapy","year":2017,"id":599749,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1537160,"name":"I. Herrero-Fernández","orcid":null,"position":1,"is_corresponding":false},{"id":1537162,"name":"A. I. Álvarez-Ríos","orcid":null,"position":2,"is_corresponding":false},{"id":1537164,"name":"M. Genebat","orcid":null,"position":3,"is_corresponding":false},{"id":1537166,"name":"M. A. Abad-Carrillo","orcid":null,"position":4,"is_corresponding":false},{"id":1537167,"name":"E. Ruiz-Mateos","orcid":null,"position":5,"is_corresponding":false},{"id":1537169,"name":"F. Pulido","orcid":null,"position":6,"is_corresponding":false},{"id":1537171,"name":"J. González-García","orcid":null,"position":7,"is_corresponding":false},{"id":1537172,"name":"M. Montero","orcid":null,"position":8,"is_corresponding":false},{"id":1537174,"name":"E. Bernal-Morell","orcid":null,"position":9,"is_corresponding":false},{"id":202544,"name":"F. Vidal","orcid":null,"position":10,"is_corresponding":false},{"id":1537175,"name":"M. Leal","orcid":null,"position":11,"is_corresponding":false},{"id":1537176,"name":"Y. M. 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Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. 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