{"doi":"10.1128/aac.00431-23","title":"Unexpectedly low drug exposures among Ugandan patients with TB and HIV receiving high-dose rifampicin","abstract":"We characterized the pharmacokinetics of standard- and high-dose rifampicin in Ugandan adults with tuberculosis and HIV taking dolutegravir- or efavirenz-based antiretroviral therapy. A liver model with saturable hepatic extraction adequately described the data, and the increase in exposure between high and standard doses was 4.7-fold. This was lower than what previous reports of dose-exposure nonlinearity would predict and was ascribed to 38% lower bioavailability of the rifampicin-only top-up formulation compared to the fixed-dose combination.","journal":"Antimicrobial Agents and Chemotherapy","year":2023,"id":377810,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":376088,"name":"Kamunkhwala Gausi","orcid":"0000-0002-9002-8087","position":1,"is_corresponding":false},{"id":897930,"name":"Ruth Nabisere","orcid":null,"position":2,"is_corresponding":false},{"id":897333,"name":"Joseph Musaazi","orcid":"0000-0001-5245-4571","position":3,"is_corresponding":false},{"id":644487,"name":"Allan Buzibye","orcid":"0000-0001-5874-3219","position":4,"is_corresponding":false},{"id":897336,"name":"Denis Omali","orcid":"0000-0001-6557-8928","position":5,"is_corresponding":false},{"id":644488,"name":"Rob E. Aarnoutse","orcid":"0000-0001-8925-969X","position":6,"is_corresponding":false},{"id":366192,"name":"Mohammed Lamorde","orcid":"0000-0003-2218-6822","position":7,"is_corresponding":false},{"id":346876,"name":"Kelly E. Dooley","orcid":"0000-0001-9013-5256","position":8,"is_corresponding":false},{"id":661905,"name":"Derek J. Sloan","orcid":"0000-0002-7888-5449","position":9,"is_corresponding":false},{"id":445889,"name":"Christine Sekaggya‐Wiltshire","orcid":"0000-0001-9247-2950","position":10,"is_corresponding":false},{"id":308900,"name":"Paolo Denti","orcid":"0000-0001-7494-079X","position":11,"is_corresponding":false},{"id":784506,"name":"Allan Kengo","orcid":"0009-0000-5084-4314","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T01:16:40.346877Z","pmid":"37850737","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}