{"doi":"10.1128/aac.00414-22","title":"A Novel Oral GyrB/ParE Dual Binding Inhibitor Effective against Multidrug-Resistant <i>Neisseria gonorrhoeae</i> and Other High-Threat Pathogens","abstract":"activity against high-threat Gram-positive organisms, and JSF-2659 was shown in a deep tissue model of vancomycin-resistant Staphylococcus aureus (VRSA) and a model of Clostridioides difficile-induced colitis to be highly efficacious and protective. JSF-2659 is a novel preclinical drug candidate against high-threat multidrug resistant organisms with low potential to develop new resistance.","journal":"Antimicrobial Agents and Chemotherapy","year":2022,"id":274302,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336880,"name":"Riccardo Russo","orcid":"0000-0002-2900-0659","position":1,"is_corresponding":false},{"id":942805,"name":"Landon Westfall","orcid":null,"position":2,"is_corresponding":false},{"id":338339,"name":"Riju Shrestha","orcid":null,"position":3,"is_corresponding":false},{"id":317196,"name":"Matthew Zimmerman","orcid":"0000-0002-4390-3555","position":4,"is_corresponding":false},{"id":283116,"name":"Véronique Dartois","orcid":"0000-0001-9470-5009","position":5,"is_corresponding":false},{"id":942806,"name":"Natalia Kurepina","orcid":null,"position":6,"is_corresponding":false},{"id":231558,"name":"Barry N. Kreiswirth","orcid":"0000-0002-0243-131X","position":7,"is_corresponding":false},{"id":942807,"name":"Eric Singleton","orcid":null,"position":8,"is_corresponding":false},{"id":745045,"name":"Shaogang Li","orcid":"0000-0002-4939-3920","position":9,"is_corresponding":false},{"id":942808,"name":"Nisha Mittal","orcid":null,"position":10,"is_corresponding":false},{"id":719948,"name":"Yong‐Mo Ahn","orcid":null,"position":11,"is_corresponding":false},{"id":942809,"name":"Joseph Bilotta","orcid":null,"position":12,"is_corresponding":false},{"id":277687,"name":"Kristie L. Connolly","orcid":"0000-0002-7516-4427","position":13,"is_corresponding":false},{"id":277694,"name":"Ann E. Jerse","orcid":"0000-0002-5118-3172","position":14,"is_corresponding":false},{"id":336889,"name":"Joel S. Freundlich","orcid":"0000-0002-3411-3455","position":15,"is_corresponding":false},{"id":336885,"name":"David S. Perlin","orcid":"0000-0002-1268-5524","position":16,"is_corresponding":false},{"id":336884,"name":"Steven Park","orcid":"0000-0002-6757-1559","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T00:28:07.776043Z","pmid":"35972242","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}