{"doi":"10.1128/aac.00246-20","title":"Polymyxin Triple Combinations against Polymyxin-Resistant, Multidrug-Resistant, KPC-Producing Klebsiella pneumoniae","abstract":"Resistance to polymyxin antibiotics is increasing. Without new antibiotic classes, combination therapy is often required. We systematically investigated bacterial killing with polymyxin-based combinations against multidrug-resistant (including polymyxin-resistant), carbapenemase-producing Klebsiella pneumoniae . Monotherapies and double- and triple-combination therapies were compared to identify the most efficacious treatment using static time-kill studies (24 h, six isolates), an in vitro pharmacokinetic/pharmacodynamic model (IVM; 48 h, two isolates), and the mouse thigh infection model (24 h, six isolates).","journal":"Antimicrobial Agents and Chemotherapy","year":2020,"id":69073,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":340484,"name":"Irene Galani","orcid":"0000-0001-6455-9848","position":1,"is_corresponding":false},{"id":366260,"name":"Heidi H. Yu","orcid":"0000-0002-3337-1399","position":2,"is_corresponding":false},{"id":256061,"name":"Jiping Wang","orcid":"0000-0002-7466-098X","position":3,"is_corresponding":false},{"id":366261,"name":"Ke Chen","orcid":"0000-0003-3148-9921","position":4,"is_corresponding":false},{"id":366262,"name":"Hasini Wickremasinghe","orcid":"0000-0003-1347-7484","position":5,"is_corresponding":false},{"id":340485,"name":"Ilias Karaiskos","orcid":"0000-0002-2226-0239","position":6,"is_corresponding":false},{"id":366263,"name":"Phillip J. Bergen","orcid":"0000-0001-5671-9880","position":7,"is_corresponding":false},{"id":321535,"name":"Jinxin Zhao","orcid":"0000-0002-0604-3541","position":8,"is_corresponding":false},{"id":326951,"name":"Tony Velkov","orcid":"0000-0002-0017-7952","position":9,"is_corresponding":false},{"id":340487,"name":"Helen Giamarellou","orcid":"0000-0002-7387-5065","position":10,"is_corresponding":false},{"id":366264,"name":"Yu‐Wei Lin","orcid":"0000-0003-2045-6876","position":11,"is_corresponding":false},{"id":298094,"name":"Brian T. Tsuji","orcid":"0000-0002-2413-2118","position":12,"is_corresponding":false},{"id":258541,"name":"Jian Li","orcid":"0000-0001-7953-8230","position":13,"is_corresponding":false},{"id":341160,"name":"Su Mon Aye","orcid":null,"position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-18T21:42:22.705573Z","pmid":"32393492","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}