{"doi":"10.1128/aac.00174-24","title":"<i>In vitro</i> activity of cefoxitin, imipenem, meropenem, and ceftaroline in combination with vaborbactam against <i>Mycobacterium abscessus</i>","abstract":"ABSTRACT Mycobacterium abscessus (MAB) infections pose a growing public health threat. Here, we assessed the in vitro activity of the boronic acid-based β-lactamase inhibitor, vaborbactam, with different β-lactams against 100 clinical MAB isolates. Enhanced activity was observed with meropenem and ceftaroline with vaborbactam (1- and &gt;4-fold MIC 50 / 90 reduction). CRISPRi-mediated bla MAB gene knockdown showed a fourfold MIC reduction to ceftaroline but not the other β-lactams. Our findings demonstrate vaborbactam’s potential in combination therapy against MAB infections.","journal":"Antimicrobial Agents and Chemotherapy","year":2024,"id":463868,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":729401,"name":"Elena Shashkina","orcid":null,"position":1,"is_corresponding":false},{"id":942806,"name":"Natalia Kurepina","orcid":null,"position":2,"is_corresponding":false},{"id":671922,"name":"Vinicius Calado Nogueira de Moura","orcid":"0000-0001-5874-0958","position":3,"is_corresponding":false},{"id":108175,"name":"Charles L. Daley","orcid":"0000-0003-3324-926X","position":4,"is_corresponding":false},{"id":231558,"name":"Barry N. Kreiswirth","orcid":"0000-0002-0243-131X","position":5,"is_corresponding":false},{"id":231557,"name":"Liang Chen","orcid":"0000-0001-5845-2235","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:04:33.257852Z","pmid":"38557171","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}