{"doi":"10.1126/stke.4112007tw408","title":"Dynamic Developmental Gene Regulation","abstract":"<jats:p>\n            Gene regulatory networks control metazoan development and determine which transcription factors will regulate which regulatory genes. However, development is a dynamic process that is driven by continuous change in time and space. Smith\n            <jats:italic>et al</jats:italic>\n            . now show how a network subcircuit controls a circular pattern of regulatory gene expression that sweeps outward from the vegetal pole of the sea urchin embryo and extinguishes its own activity in the more central regions to establish a dynamic regulatory pattern of gene expression.\n          </jats:p>\n          <jats:p>\n            J. Smith, C. Theodoris, E. H. Davidson, A gene regulatory network subcircuit drives a dynamic pattern of gene expression.\n            <jats:italic>Science</jats:italic>\n            <jats:bold>318</jats:bold>\n            , 794-797 (2007).\n            <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"url\" xlink:href=\"http://stke.sciencemag.org/cgi/content/abstract/sci;318/5851/794\">[Abstract]</jats:ext-link>\n            <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"url\" xlink:href=\"http://stke.sciencemag.org/cgi/content/full/sci;318/5851/794\">[Full Text]</jats:ext-link>\n          </jats:p>","journal":"Science's STKE","year":2007,"id":21583,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":138418,"name":"Beverly A. Purnell","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21071399","pmcid":null,"openalex_id":"https://openalex.org/W1964326841","authors":[],"funders":[],"total_grants":0,"fwci":0.3483,"citation_percentile":0.71024485,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://syndication.highwire.org/content/doi/10.1126/stke.4112007tw408","host_type":"publisher"},{"url":"https://doi.org/10.1126/stke.4112007tw408","host_type":"journal"}],"fields_of_study":["Science, Research, and Medicine","Ocean Acidification Effects and Responses","Environmental Science and Water Management","Biology"],"mesh_terms":[],"keywords":["Gene regulatory network","Gene expression","Gene","Regulation of gene expression","Biology","Transcription factor","Regulator gene","Genetics","Regulatory sequence","Transcriptional regulation","Computational biology","Cis-regulatory module","Promoter"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T16:18:02.717309Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}