{"doi":"10.1126/scitranslmed.ads8680","title":"Epidemiological and antigenic inferences from serological cross-reactivity among arboviruses","abstract":"Multiplex immunoassays can facilitate the parallel measurement of antibody responses against multiple antigenically related pathogens, generating a wealth of high-dimensional data that depict complex antibody-antigen relationships. In this study, we developed a generalizable analytical framework to maximize inferences from multipathogen serological studies. We fit the model to measurements of immunoglobulin antibody binding against 10 arboviral pathogens from a cross-sectional study in northwest Bangladesh with 1453 participants. We used our framework to jointly infer the prevalence of each pathogen by location and age as well as between-pathogen antibody cross-reactivity. Reconstructing immunological profiles, we found evidence of endemic transmission of Japanese encephalitis virus and recent outbreaks of dengue and chikungunya viruses in this district. Our estimates of antibody cross-reactivity were highly correlated with phylogenetic distances inferred from genetic data [correlation coefficient ( r ) = 0.94], demonstrating how antigenic landscapes can be inferred from population-level serological studies. Furthermore, we showed how our framework could be used to identify the presence of antigenically related pathogens that were not directly tested for, representing a potential opportunity for the detection of emerging pathogens. The presented analytical framework offers a tool that can be applied to a growing number of multipathogen studies and will help support the integration of serological testing into disease surveillance platforms.","journal":"Science Translational Medicine","year":2025,"id":524929,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9324,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":686410,"name":"Nathanaël Hozé","orcid":"0000-0002-3977-8966","position":1,"is_corresponding":false},{"id":565810,"name":"Noémie Lefrancq","orcid":"0000-0001-5991-6169","position":2,"is_corresponding":false},{"id":905233,"name":"Gabriel Ribeiro dos Santos","orcid":"0000-0003-4668-8755","position":3,"is_corresponding":false},{"id":874070,"name":"Damien Hoinard","orcid":"0009-0000-1453-4132","position":4,"is_corresponding":false},{"id":242151,"name":"Mohammed Ziaur Rahman","orcid":"0000-0002-4103-4835","position":5,"is_corresponding":false},{"id":352716,"name":"Kishor Kumar Paul","orcid":"0000-0002-6054-3571","position":6,"is_corresponding":false},{"id":1312539,"name":"Abu Mohd Naser","orcid":"0000-0002-1347-4446","position":7,"is_corresponding":false},{"id":590113,"name":"Mohammad Shafiul Alam","orcid":"0000-0001-8330-5499","position":8,"is_corresponding":false},{"id":388217,"name":"Mohammad Enayet Hossain","orcid":"0000-0001-5511-1857","position":9,"is_corresponding":false},{"id":874071,"name":"Jessica Vanhomwegen","orcid":"0000-0002-7879-1485","position":10,"is_corresponding":false},{"id":228760,"name":"Simon Cauchemez","orcid":"0000-0001-9186-4549","position":11,"is_corresponding":false},{"id":328825,"name":"Emily S. Gurley","orcid":"0000-0002-8648-9403","position":12,"is_corresponding":false},{"id":60899,"name":"Henrik Salje","orcid":"0000-0003-3626-4254","position":13,"is_corresponding":false},{"id":998329,"name":"Megan O’Driscoll","orcid":"0000-0002-7972-5703","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T02:50:16.562292Z","pmid":"41296827","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}