{"doi":"10.1126/scitranslmed.adf6376","title":"The anti-CD40L monoclonal antibody AT-1501 promotes islet and kidney allograft survival and function in nonhuman primates","abstract":"Prior studies of anti-CD40 ligand (CD40L)-based immunosuppression demonstrated effective prevention of islet and kidney allograft rejection in nonhuman primate models; however, clinical development was halted because of thromboembolic complications. An anti-CD40L-specific monoclonal antibody, AT-1501 (Tegoprubart), was engineered to minimize risk of thromboembolic complications by reducing binding to Fcγ receptors expressed on platelets while preserving binding to CD40L. AT-1501 was tested in both a cynomolgus macaque model of intrahepatic islet allotransplantation and a rhesus macaque model of kidney allotransplantation. AT-1501 monotherapy led to long-term graft survival in both islet and kidney transplant models, confirming its immunosuppressive potential. Furthermore, AT-1501-based regimens after islet transplant resulted in higher C-peptide, greater appetite leading to weight gain, and reduced occurrence of cytomegalovirus reactivation compared with conventional immunosuppression. These data support AT-1501 as a safe and effective agent to promote both islet and kidney allograft survival and function in nonhuman primate models, warranting further testing in clinical trials.","journal":"Science Translational Medicine","year":2023,"id":318934,"datarank":0.6166310796259968,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":0.0,"self_endowment_contribution":0.6166310796259968,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":721003,"name":"Dora M. Berman","orcid":"0000-0001-7817-9387","position":1,"is_corresponding":false},{"id":902001,"name":"Isabel DeLaura","orcid":"0000-0002-2340-0918","position":2,"is_corresponding":false},{"id":902003,"name":"Qimeng Gao","orcid":"0000-0002-2456-7672","position":3,"is_corresponding":false},{"id":720998,"name":"Melissa A. Willman","orcid":"0000-0002-0688-5490","position":4,"is_corresponding":false},{"id":850044,"name":"Allison D. Miller","orcid":"0000-0001-8191-0943","position":5,"is_corresponding":false},{"id":1027023,"name":"Alan Gill","orcid":"0000-0001-9025-495X","position":6,"is_corresponding":false},{"id":1027585,"name":"Cindy Gill","orcid":null,"position":7,"is_corresponding":false},{"id":1027586,"name":"Steve Perrin","orcid":null,"position":8,"is_corresponding":false},{"id":316559,"name":"Camillo Ricordi","orcid":"0000-0001-8092-7153","position":9,"is_corresponding":false},{"id":542889,"name":"Phillip Ruiz","orcid":"0000-0003-2291-4594","position":10,"is_corresponding":false},{"id":656431,"name":"Mingqing Song","orcid":"0000-0002-2462-9351","position":11,"is_corresponding":false},{"id":902002,"name":"Joseph M. Ladowski","orcid":"0000-0002-6787-3725","position":12,"is_corresponding":false},{"id":423696,"name":"Allan D. Kirk","orcid":"0000-0003-2004-5962","position":13,"is_corresponding":false},{"id":513360,"name":"Norma S. Kenyon","orcid":"0000-0003-3157-339X","position":14,"is_corresponding":false},{"id":902000,"name":"Imran J. Anwar","orcid":"0000-0002-5075-4148","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:07:06.454099Z","pmid":"37647390","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}