{"doi":"10.1126/scitranslmed.abd7522","title":"APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function","abstract":"(5XE4) that have prominent CAA and parenchymal plaque pathology to assess the efficacy of HAE-4 compared to an Aβ antibody that removes parenchymal Aβ but increases ARIA in humans. In chronically treated 5XE4 mice, HAE-4 reduced Aβ deposition including CAA compared to a control antibody, whereas the anti-Aβ antibody had no effect on CAA. Furthermore, the anti-Aβ antibody exacerbated microhemorrhage severity, which highly correlated with reactive astrocytes surrounding CAA. In contrast, HAE-4 did not stimulate microhemorrhages and instead rescued CAA-induced cerebrovascular dysfunction in leptomeningeal arteries in vivo. HAE-4 not only reduced amyloid but also dampened reactive microglial, astrocytic, and proinflammatory-associated genes in the cortex. These results suggest that targeting APOE in the core of both CAA and plaques could ameliorate amyloid pathology while protecting cerebrovascular integrity and function.","journal":"Science Translational Medicine","year":2021,"id":146736,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":198,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9612,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":623696,"name":"Hong Jiang","orcid":"0000-0001-6480-7469","position":1,"is_corresponding":false},{"id":236541,"name":"Javier Remolina Serrano","orcid":"0000-0002-5937-0212","position":2,"is_corresponding":false},{"id":624726,"name":"Ernesto R. Gonzales","orcid":null,"position":3,"is_corresponding":false},{"id":623697,"name":"Chao Wang","orcid":"0000-0002-2987-1729","position":4,"is_corresponding":false},{"id":236536,"name":"Maud Gratuze","orcid":"0000-0002-1552-8815","position":5,"is_corresponding":false},{"id":623698,"name":"Rosa Hoyle","orcid":"0000-0003-3383-424X","position":6,"is_corresponding":false},{"id":624727,"name":"Nga Bien‐Ly","orcid":null,"position":7,"is_corresponding":false},{"id":623699,"name":"Adam P. Silverman","orcid":"0000-0003-1749-6607","position":8,"is_corresponding":false},{"id":250210,"name":"Patrick M. Sullivan","orcid":"0000-0001-8402-2634","position":9,"is_corresponding":false},{"id":621732,"name":"Ryan J. Watts","orcid":"0000-0002-4973-5089","position":10,"is_corresponding":false},{"id":236544,"name":"Jason D. Ulrich","orcid":"0000-0002-4743-926X","position":11,"is_corresponding":false},{"id":394789,"name":"Gregory J. Zipfel","orcid":"0000-0003-2737-9084","position":12,"is_corresponding":false},{"id":27592,"name":"David M. Holtzman","orcid":"0000-0002-3400-0856","position":13,"is_corresponding":false},{"id":236539,"name":"Monica Xiong","orcid":"0000-0002-8398-1814","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T23:42:24.567796Z","pmid":"33597265","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}