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Repurposing the antidiabetic drug metformin lowered pathogenic EZHIP, increased H3K27me3, and suppressed tumor growth, suggesting that targeting integrated metabolic/epigenetic pathways is a potential therapeutic strategy for treating childhood ependymomas.","journal":"Science Translational Medicine","year":2021,"id":155384,"datarank":1.4417076545739715,"base_score":4.0943445622221,"endowment":4.0943445622221,"self_citation_contribution":0.6141516843333151,"citation_network_contribution":0.8275559702406564,"self_endowment_contribution":0.6141516843333151,"citer_contribution":0.8275559702406564,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":43,"citers_with_citation_signal":36,"citers_with_endowment":36,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":260740,"name":"Benita Tamrazi","orcid":"0000-0003-4795-8454","position":1,"is_corresponding":false},{"id":657505,"name":"Derek Dang","orcid":"0000-0003-2071-4898","position":2,"is_corresponding":false},{"id":331939,"name":"Chan Chung","orcid":"0000-0003-0510-8996","position":3,"is_corresponding":false},{"id":657506,"name":"Stefan R. 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