{"doi":"10.1126/scitranslmed.aaz4589","title":"A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components","abstract":"expression correlated with expression of genes encoding SAC proteins and was associated with a worse clinical outcome. These data revealed the YAP/FOXM1 axis as a central regulator of EMT-associated EGFR TKI resistance and that this pathway, along with SAC components, are therapeutic vulnerabilities for targeting this multidrug-resistant phenotype.","journal":"Science Translational Medicine","year":2020,"id":50737,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":181,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":250649,"name":"Huiying Sun","orcid":"0000-0001-8916-9387","position":1,"is_corresponding":false},{"id":250650,"name":"Jacqulyne Robichaux","orcid":"0000-0001-8812-7054","position":2,"is_corresponding":false},{"id":250651,"name":"Matthias Pfeifer","orcid":"0000-0003-0065-9211","position":3,"is_corresponding":false},{"id":250652,"name":"Ultan McDermott","orcid":"0000-0001-9032-4700","position":4,"is_corresponding":false},{"id":250653,"name":"Jon Travers","orcid":"0009-0002-8923-8789","position":5,"is_corresponding":false},{"id":228163,"name":"Lixia Diao","orcid":"0000-0001-6995-4492","position":6,"is_corresponding":false},{"id":18350,"name":"Yuanxin Xi","orcid":"0000-0001-5509-2043","position":7,"is_corresponding":false},{"id":250654,"name":"Pan Tong","orcid":"0000-0002-8475-4437","position":8,"is_corresponding":false},{"id":250655,"name":"Li Shen","orcid":"0000-0001-8427-9448","position":9,"is_corresponding":false},{"id":250656,"name":"Mia Hofstad","orcid":"0000-0001-5530-7817","position":10,"is_corresponding":false},{"id":250657,"name":"Masanori Kawakami","orcid":"0000-0003-0207-7434","position":11,"is_corresponding":false},{"id":52033,"name":"Xiuning Le","orcid":"0000-0002-8554-1185","position":12,"is_corresponding":false},{"id":250658,"name":"Xi Liu","orcid":"0000-0002-8700-632X","position":13,"is_corresponding":false},{"id":250659,"name":"You-Hong Fan","orcid":"0000-0002-1668-8271","position":14,"is_corresponding":false},{"id":250660,"name":"Alissa Poteete","orcid":"0000-0002-6091-2840","position":15,"is_corresponding":false},{"id":250661,"name":"Limei Hu","orcid":"0000-0001-8899-0771","position":16,"is_corresponding":false},{"id":247601,"name":"Marcelo V. Negrão","orcid":"0000-0001-8938-6699","position":17,"is_corresponding":false},{"id":247606,"name":"Hai T. Tran","orcid":"0000-0003-4065-9355","position":18,"is_corresponding":false},{"id":250662,"name":"Ethan Dmitrovsky","orcid":"0000-0002-2895-8208","position":19,"is_corresponding":false},{"id":228161,"name":"David H. Peng","orcid":"0000-0003-0511-1888","position":20,"is_corresponding":false},{"id":228170,"name":"Don L. Gibbons","orcid":"0000-0003-2362-3094","position":21,"is_corresponding":false},{"id":228165,"name":"Jing Wang","orcid":"0000-0002-5398-0802","position":22,"is_corresponding":false},{"id":227923,"name":"John V. Heymach","orcid":"0000-0001-9068-8942","position":23,"is_corresponding":false},{"id":250648,"name":"Monique B. Nilsson","orcid":"0000-0002-0975-8833","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-18T20:39:29.006085Z","pmid":"32878980","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}