{"doi":"10.1126/scisignal.adh2783","title":"Exercise-induced BDNF promotes PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery","abstract":"Post-exercise recovery is essential to resolve metabolic perturbations and promote long-term cellular remodeling in response to exercise. Here, we report that muscle-generated brain-derived neurotrophic factor (BDNF) elicits post-exercise recovery and metabolic reprogramming in skeletal muscle. BDNF increased the post-exercise expression of the gene encoding PPARδ (peroxisome proliferator–activated receptor δ), a transcription factor that is a master regulator of lipid metabolism. After exercise, mice with muscle-specific Bdnf knockout ( MBKO ) exhibited impairments in PPARδ-regulated metabolic gene expression, decreased intramuscular lipid content, reduced β-oxidation, and dysregulated mitochondrial dynamics. Moreover, MBKO mice required a longer period to recover from a bout of exercise and did not show increases in exercise-induced endurance capacity. Feeding naïve mice with the bioavailable BDNF mimetic 7,8-dihydroxyflavone resulted in effects that mimicked exercise-induced adaptations, including improved exercise capacity. Together, our findings reveal that BDNF is an essential myokine for exercise-induced metabolic recovery and remodeling in skeletal muscle.","journal":"Science Signaling","year":2024,"id":419594,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":305411,"name":"Chun Fai Ng","orcid":"0000-0003-2178-4214","position":1,"is_corresponding":false},{"id":1209578,"name":"Brian Pak Shing Pang","orcid":"0000-0003-1791-1436","position":2,"is_corresponding":false},{"id":1210311,"name":"Miaojia Hang","orcid":null,"position":3,"is_corresponding":false},{"id":1209579,"name":"Margaret Chui Ling Tse","orcid":"0000-0002-0443-0038","position":4,"is_corresponding":false},{"id":1210312,"name":"Elsie Chit Yu Iu","orcid":null,"position":5,"is_corresponding":false},{"id":1210313,"name":"Xin Ci Ooi","orcid":null,"position":6,"is_corresponding":false},{"id":1209580,"name":"Xiuying Yang","orcid":"0000-0001-8500-3128","position":7,"is_corresponding":false},{"id":245309,"name":"Jason K. Kim","orcid":"0000-0002-7185-042X","position":8,"is_corresponding":false},{"id":835992,"name":"Chi Wai Lee","orcid":"0000-0003-4619-3189","position":9,"is_corresponding":false},{"id":1209581,"name":"Chi Bun Chan","orcid":"0000-0002-2787-9575","position":10,"is_corresponding":false},{"id":1209577,"name":"Wing Suen Chan","orcid":"0000-0003-3129-6089","position":0,"is_corresponding":true}],"reference_count":90,"raw_metadata":null,"created_at":"2026-07-19T01:57:19.937291Z","pmid":"38502732","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}