{"doi":"10.1126/scisignal.adg7867","title":"Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection","abstract":"Type I interferons (IFNs) are critical for the antiviral immune response, and fine-tuning type I IFN production is critical to effectively clearing viruses without causing harmful immunopathology. We showed that the transcription factor Miz1 epigenetically repressed the expression of genes encoding type I IFNs in mouse lung epithelial cells by recruiting histone deacetylase 1 (HDAC1) to the promoters of Ifna and Ifnb . Loss of function of Miz1 resulted in augmented production of these type I IFNs during influenza A virus (IAV) infection, leading to improved viral clearance in vitro and in vivo. IAV infection induced Miz1 accumulation by promoting the cullin-4B (CUL4B)–mediated ubiquitylation and degradation of the E3 ubiquitin ligase Mule (Mcl-1 ubiquitin ligase E3; also known as Huwe1 or Arf-BP1), which targets Miz1 for degradation. As a result, Miz1 accumulation limited type I IFN production and favored viral replication. This study reveals a previously unrecognized function of Miz1 in regulating antiviral defense and a potential mechanism for influenza viruses to evade host immune defense.","journal":"Science Signaling","year":2024,"id":442227,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1255689,"name":"Vinothini Arunagiri","orcid":"0000-0002-2824-7609","position":1,"is_corresponding":false},{"id":511243,"name":"Hanh Chi Do-Umehara","orcid":"0000-0002-3368-1602","position":2,"is_corresponding":false},{"id":944965,"name":"Cong Chen","orcid":"0000-0003-0875-7473","position":3,"is_corresponding":false},{"id":1256056,"name":"Shuyin Gu","orcid":null,"position":4,"is_corresponding":false},{"id":1256057,"name":"Indrani Biswas","orcid":null,"position":5,"is_corresponding":false},{"id":270775,"name":"Karen M. Ridge","orcid":"0000-0001-7784-0014","position":6,"is_corresponding":false},{"id":230873,"name":"G. R. Scott Budinger","orcid":"0000-0002-3114-5208","position":7,"is_corresponding":false},{"id":593434,"name":"Shuwen Liu","orcid":"0000-0001-6346-5006","position":8,"is_corresponding":false},{"id":511248,"name":"Jing Liu","orcid":"0000-0003-4699-1375","position":9,"is_corresponding":false},{"id":1255688,"name":"Wenjiao Wu","orcid":"0000-0003-3337-0852","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T02:01:15.932178Z","pmid":"38593156","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}