{"doi":"10.1126/scisignal.abc9089","title":"Fluoxetine restrains allergic inflammation by targeting an FcɛRI-ATP positive feedback loop in mast cells","abstract":"There is a clinical need for new treatment options addressing allergic disease. Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that have anti-inflammatory properties. We tested the effects of the SSRI fluoxetine on IgE-induced function of mast cells, which are critical effectors of allergic inflammation. We showed that fluoxetine treatment of murine or human mast cells reduced IgE-mediated degranulation, cytokine production, and inflammatory lipid secretion, as well as signaling mediated by the mast cell activator ATP. In a mouse model of systemic anaphylaxis, fluoxetine reduced hypothermia and cytokine production. Fluoxetine was also effective in a model of allergic airway inflammation, where it reduced bronchial responsiveness and inflammation. These data show that fluoxetine suppresses mast cell activation by impeding an FcɛRI-ATP positive feedback loop and support the potential repurposing of this SSRI for use in allergic disease.","journal":"Science Signaling","year":2023,"id":377565,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":450962,"name":"Marcela T Taruselli","orcid":"0000-0002-7965-4335","position":1,"is_corresponding":false},{"id":450964,"name":"Sydney Ann Kee","orcid":"0000-0002-1254-4828","position":2,"is_corresponding":false},{"id":452060,"name":"Jordan Dailey","orcid":null,"position":3,"is_corresponding":false},{"id":781328,"name":"Neha Pondicherry","orcid":"0000-0003-2300-7902","position":4,"is_corresponding":false},{"id":1141611,"name":"Paula A. Gajewski-Kurdziel","orcid":null,"position":5,"is_corresponding":false},{"id":417221,"name":"Matthew Zellner","orcid":null,"position":6,"is_corresponding":false},{"id":489004,"name":"Daniel Stephenson","orcid":"0000-0002-5698-3400","position":7,"is_corresponding":false},{"id":862338,"name":"H. Patrick MacKnight","orcid":"0000-0003-3232-6155","position":8,"is_corresponding":false},{"id":450966,"name":"David B. Straus","orcid":"0000-0003-1989-8255","position":9,"is_corresponding":false},{"id":890249,"name":"Roma Kankaria","orcid":"0000-0002-5730-0739","position":10,"is_corresponding":false},{"id":723025,"name":"Kaitlyn G. Jackson","orcid":"0000-0003-2663-9593","position":11,"is_corresponding":false},{"id":300581,"name":"Alena Chumanevich","orcid":null,"position":12,"is_corresponding":false},{"id":119162,"name":"Yoshihiro Fukuoka","orcid":null,"position":13,"is_corresponding":false},{"id":242062,"name":"Lawrence B. Schwartz","orcid":"0000-0002-4379-6729","position":14,"is_corresponding":false},{"id":459255,"name":"Randy Blakely","orcid":"0000-0002-2182-6966","position":15,"is_corresponding":false},{"id":299696,"name":"Carole A. Oskeritzian","orcid":"0000-0003-1380-9186","position":16,"is_corresponding":false},{"id":489008,"name":"Charles E. Chalfant","orcid":"0000-0002-5844-5235","position":17,"is_corresponding":false},{"id":274831,"name":"Rebecca Martin","orcid":"0000-0001-9948-5463","position":18,"is_corresponding":false},{"id":1141234,"name":"John J. Ryan","orcid":"0000-0002-6808-9385","position":19,"is_corresponding":false},{"id":431919,"name":"Tamara T. Haque","orcid":"0000-0003-4436-9558","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-19T01:16:40.346877Z","pmid":"37699080","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}