{"doi":"10.1126/scisignal.abc4078","title":"Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1","abstract":"<jats:p>Mutations that dysregulate a protein complex may promote cancer metastasis by enhancing Rac1 activation.</jats:p>","journal":"Science Signaling","year":2021,"id":619835,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1599803,"name":"Christina M. Lucato","orcid":null,"position":1,"is_corresponding":false},{"id":1599804,"name":"Elsa A. Marquez","orcid":null,"position":2,"is_corresponding":false},{"id":1397132,"name":"Yong-Gang Chang","orcid":null,"position":3,"is_corresponding":false},{"id":1599805,"name":"Srgjan Civciristov","orcid":null,"position":4,"is_corresponding":false},{"id":1575887,"name":"Chantel Mastos","orcid":null,"position":5,"is_corresponding":false},{"id":1575881,"name":"Christopher J. Lupton","orcid":null,"position":6,"is_corresponding":false},{"id":813607,"name":"Cheng Huang","orcid":"0000-0002-4575-1233","position":7,"is_corresponding":false},{"id":478732,"name":"Hans Elmlund","orcid":"0000-0002-6992-0601","position":8,"is_corresponding":false},{"id":705199,"name":"Ralf B. Schittenhelm","orcid":"0000-0001-8738-1878","position":9,"is_corresponding":false},{"id":192205,"name":"Christina A. Mitchell","orcid":null,"position":10,"is_corresponding":false},{"id":482917,"name":"James C. Whisstock","orcid":"0000-0003-4200-5611","position":11,"is_corresponding":false},{"id":700986,"name":"Michelle L. Halls","orcid":"0000-0001-8555-8959","position":12,"is_corresponding":false},{"id":1384914,"name":"Andrew M. Ellisdon","orcid":"0000-0002-2248-9914","position":13,"is_corresponding":false},{"id":1526030,"name":"Laura D’Andrea","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1","abstract":"<jats:p>Mutations that dysregulate a protein complex may promote cancer metastasis by enhancing Rac1 activation.</jats:p>","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33947796","pmcid":null,"openalex_id":"https://openalex.org/W3157136242","authors":[],"funders":[{"funder_name":"National Health and Medical Research Council","grant_id":"APP1146578","title":null},{"funder_name":"National Health and Medical Research Council","grant_id":"APP1128120","title":null},{"funder_name":"National Health and Medical Research Council","grant_id":"APP1104614","title":null},{"funder_name":"Skretting Aquaculture Research Centre","grant_id":"1061687","title":null},{"funder_name":"Alzheimer Nadační Fond","grant_id":"","title":null},{"funder_name":"Bonneville Power Administration","grant_id":"","title":null}],"total_grants":6,"fwci":0.793,"citation_percentile":0.6978374,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":4},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.osti.gov/biblio/1781847","host_type":"repository"},{"url":"https://www.osti.gov/biblio/1781847","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1126/scisignal.abc4078","host_type":"publisher"},{"url":"https://www.science.org/doi/pdf/10.1126/scisignal.abc4078","host_type":"publisher"},{"url":"https://doi.org/10.1126/scisignal.abc4078","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33947796","host_type":"repository"}],"fields_of_study":["PI3K/AKT/mTOR signaling in cancer","Coagulation, Bradykinin, Polyphosphates, and Angioedema","Protein Kinase Regulation and GTPase Signaling","Guanine Nucleotide Exchange Factors","Humans","Mutation","Neoplasms","PTEN Phosphohydrolase","Phosphatidylinositol 3-Kinases","Signal Transduction","rac1 GTP-Binding Protein"],"mesh_terms":["Humans","Mutation","Neoplasms","Signal Transduction","Phosphatidylinositol 3-Kinases","Guanine Nucleotide Exchange Factors","rac1 GTP-Binding Protein","PTEN Phosphohydrolase"],"keywords":["RAC1","PTEN","Cancer research","Signal transduction","Metastasis","Cancer","Biology","Mutation","Gene","Cell biology","Genetics","PI3K/AKT/mTOR pathway"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T08:46:04.546431Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}